Table 2.
Relationship between IDH1&IDH2 and TET2 Mutation and the Different Laboratory and Clinical Findings in Adult Acute Myeloid Leukemia Patients
| IDH1&IDH2 | TET2 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Either IDH1 and or IDH2 mutant | both wild | P value | TET2 Mutant N=72 (51.1%) | TET2 Wild N=69 (48.9%) | p value | ||||||||
| Gende (n=141) | |||||||||||||
| Female | 4 (36.4) | 61 (46.9) | 0.5 | 37 (51.4) | 28 (40.6) | 0.198 | |||||||
| Male | 7 (63.6) | 69 (53.1) | 35 (48.6) | 41 (59.4) | |||||||||
| Age (n=141) | |||||||||||||
| ≤40 | 5 (45.5) | 64 (49.2) | 0.81 | 35 (48.6) | 34 (49.3) | 0.937 | |||||||
| >40 | 6 (54.5) | 66 (50.8) | 37 (51.4) | 35 (50.7) | |||||||||
| TLC X109/L (n=137) | |||||||||||||
| ≤100 | 9 (90.0% | 88 (69.3) | 0.166 | 51 (73.9) | 46 (67.6) | 0.42 | |||||||
| >100 | 1 (10.0) | 39 (30.7) | 18 (26.1) | 22 (32.4) | |||||||||
| Hb g/dl (n=137) | |||||||||||||
| ≤10 | 9 (90.0) | 114 (89.8) | 0.981 | 64 (92.8) | 59 (86.8) | 0.247 | |||||||
| >10 | 1 (10.0) | 13 (10.2) | 5 (7.2) | 9 (13.2) | |||||||||
| Plts X109/L (n=137) | |||||||||||||
| ≤100 | 9 (90.0) | 103 (81.1) | 0.483 | 55 (79.7) | 57 (83.8) | 0.533 | |||||||
| >100 | 1 (10.0) | 24 (18.9) | 14 (20.3) | 11 (16.2) | |||||||||
| PB blasts %(n=141) | |||||||||||||
| ≤ 50 | 3 (27.3) | 34 (26.2) | 0.935 | 19 (26.4) | 18 (26.1) | 0.968 | |||||||
| > 50 | 8 (72.7) | 96 (73.8) | 53 (73.6) | 51 (73.9) | |||||||||
| BMA blast%(n=141) | |||||||||||||
| ≤ 50 | 1 (9.1) | 19 (14.6) | 0.614 | 7 (9.7) | 13 (18.8) | 0.121 | |||||||
| > 50 | 10 (90.9) | 111 (85.4) | 65 (90.3) | 56 (81.2) | |||||||||
| FAB classification | |||||||||||||
| M1&M2 | 8 (72.7) | 64 (52.0) | 0.187 | 40 (57.1) | 32 (50.0) | 0.407 | |||||||
| M4&M5 | 3 (27.3) | 59 (48.0) | 30 (42.9) | 32 (50.0) | |||||||||
| LNS (n=134) | |||||||||||||
| No | 6 (54.5) | 72 (58.5) | 0.797 | 37 (54.4) | 41 (62.1) | 0.366 | |||||||
| Yes | 5 (45.5) | 51 (41.5) | 31 (45.6) | 25 (37.9) | |||||||||
| Organomegally(n=134) | |||||||||||||
| No | 8 (72.7) | 77 (62.6) | 0.504 | 41 (60.3) | 44 (66.7) | 0.444 | |||||||
| Yes | 3 (27.3) | 46 (37.4) | 27 (39.7) | 22 (33.3) | |||||||||
| CD34(n=140) | |||||||||||||
| No | 6 (54.5) | 65 (50.4) | 0.791 | 35 (48.6) | 36 (52.9) | 0.609 | |||||||
| Yes | 5 (45.5) | 64 (49.6) | 37 (51.4) | 32 (47.1) | |||||||||
| DR(n=140) | |||||||||||||
| No | 3 (27.3) | 37 (28.7) | 0.921 | 15 (20.8) | 25 (36.8) | 0.037 | |||||||
| Yes | 8 (72.7) | 92 (71.3) | 57 (79.2) | 43 (63.2) | |||||||||
| CD7(n=140) | |||||||||||||
| No | 11 (100.0) | 106 (82.2) | 0.126 | 55 (76.4) | 62 (91.2) | 0.018 | |||||||
| Yes | 0 (0.0) | 23 (17.8) | 17 (23.6) | 6 (8.8) | |||||||||
| FLT3-ITD (n=141) | |||||||||||||
| Mutant | 1 (9.1) | 44 (33.8) | 0.091 | 21 (29.2) | 24 (34.8) | 0.475 | |||||||
| Wild | 10 (90.9) | 86 (66.2) | 51 (70.8) | 45 (65.2) | |||||||||
| ITD Ratio (n=45) | |||||||||||||
| ≤0.525 | 0 (0.0) | 20 (45.5) | * | 11 (52.4) | 9 (37.5) | 0.316 | |||||||
| >0.525 | 1 (100.0) | 24 (54.5 | 10 (47.6) | 15 (62.5) | |||||||||
| IDH1&IDH2 | TET2 | ||||||||||||
| Either IDH1 and or IDH2 mutant | both wild | P value | TET2 Mutant N=72 (51.1%) | TET2 Wild N=69 (48.9%) | p value | ||||||||
| TKD (n=140) | |||||||||||||
| Mutant | 0 (0.0) | 6 (4.7) | 0.465 | 6 (8.5) | 0 (0.0) | 0.014 | |||||||
| Wild | 11 (100.0) | 123 (95.3) | 65 (91.5) | 69 (100.0) | |||||||||
| NPM (n=128) | |||||||||||||
| Mutant | 1 (10.0) | 20 (16.9) | 0.569 | 8 (12.5) | 13 (20.3) | 0.233 | |||||||
| Wild | 9 (90.0) | 98 (83.1) | 56 (87.5) | 51 (79.7) | |||||||||
| DNMTA(n=139) | |||||||||||||
| Mutant | 1 (9.1) | 13 (10.2) | 0.91 | 4 (5.7) | 10 (14.5) | 0.086 | |||||||
| Wild | 10 (90.9) | 115 (89.8) | 66 (94.3) | 59 (85.5) | |||||||||
| IDH1&IDH2 | |||||||||||||
| Either IDH1 and or IDH2 mutant | - | - | 6 (8.3) | 5 (7.2) | 0.81 | ||||||||
| Both wild | - | - | 66 (91.7) | 64 (92.8) | |||||||||
| TET2 gene | |||||||||||||
| mutant TET2 gene | 6 (54.5) | 66 (50.8) | 0.81 | - | - | ||||||||
| wild TET2 gene | 5 (45.5) | 64 (49.2) | - | - | |||||||||
| BMA cellularity | |||||||||||||
| Hypercellular | 7 (63.6) | 113 (86.9) | 0.083 | 59 (81.9) | 61 (88.4) | 0.388 | |||||||
| Hypocellular | 2 (18.2) | 6 (4.6) | 4 (5.6) | 4 (5.8) | |||||||||
| Normocellular | 2 (18.2) | 11 (8.5) | 9 (12.5) | 4 (5.8) | |||||||||
| combined FLT3&NPM (n=128) | |||||||||||||
| Favourable (n=17) | 1 (5.9) | 16 (94.1) | 0.847 | 4 (6.3) | 9 (14.1) | 0.097 | |||||||
| Unfavorable (n=13) | 0 (0.0) | 13 (100) | 50 (78.1) | 39 (60.9) | |||||||||
| Intermediate (n=98) | 9 (9.2) | 89 (90.8) | 10 (15.6) | 16 (25.0) | |||||||||
*, p value cannot be calculated because of small number within strata