Table 3.
IC50 Value of Eugenol Derivative Compounds
| Compound (Number) | IC50 Exp (µmol/mL) | ΔG theory (kcal/mol) |
|---|---|---|
| 4‐[(2S)‐2,3‐dihydroxypropyl]‐2‐methoxyphenyl 2‐hydroxybenzoate (9) ** | 26.56±0.52 | -6.56 |
| 2‐methoxy‐4‐(prop‐2‐en‐1‐yl)phenyl 3,5‐dihydroxy‐4‐methoxybenzoate (4) ** | 69.10±1.65 | -6.90 |
| 2‐methoxy‐4‐(prop‐2‐en‐1‐yl)phenyl 3,4,5‐trihydroxybenzoate (3) ** | 81.52±1.58 | -6.59 |
| 4‐[(2R)‐2,3‐dihydroxypropyl]‐2‐methoxyphenyl 2‐hydroxybenzoate (10) ** | 115.44±0.56 | -5.96 |
| 2‐methoxy‐4‐(prop‐2‐en‐1‐yl)phenyl 3‐amino‐2‐hydroxybenzoate (2) ** | 135.44±0.75 | -6.47 |
| 2‐hydroxy‐4‐(prop‐2‐en‐1‐yl)phenyl 2‐hydroxybenzoate (5) | 186.16±0.74 | -5.35 |
| 4‐(2‐chloro‐3‐hydroxypropyl)‐2‐methoxyphenyl 2‐hydroxybenzoate (8) | 203.65±0.45 | -7.34 |
| 2‐methoxy‐4‐(prop‐2‐en‐1‐yl)phenyl 2‐hydroxybenzoate (1) | 264.09±0.75 | -5.45 |
| 2‐hydroxy‐4‐(prop‐2‐en‐1‐yl)phenyl 3‐amino‐2‐hydroxybenzoate (6) | 286.81±0.67 | -6.97 |
| 4‐(2‐chloro‐3‐hydroxypropyl)‐2‐hydroxyphenyl 2‐hydroxybenzoate (7) | 257.70±0.65 | -7.45 |
| Navitoclax | 0.67±0.88 | -10.26 |
| Doxorubicin | 6.11±0.76 | -5.46 |
| Gossypol | 18.32±0.83 | -5.68 |
| Eugenol | 172.41±1.14 | -4.76 |