Table 4.
Analysis Parameters of Derivative Compound Structure Activity
| Comp. Number | R1 | R2 | R3 | R4 | CMR | LogP | (LogP)2 | pKa | 1/log IC50 |
|---|---|---|---|---|---|---|---|---|---|
| (1) | OCH3 | = | = | 7.99 | 4.05 | 16.40 | 10.09 | 0.53 | |
| (2) | OH | = | = | 8.36 | 3.25 | 10.56 | 9.15 | 0.62 | |
| (3) | OCH3 | = | = | 8.29 | 3.27 | 10.69 | 16.90 | 0.77 | |
| (4) | OCH3 | = | = | 8.76 | 3.54 | 12.53 | 7.63 | 0.71 | |
| (5) | OH | = | = | 8.32 | 2.17 | 4.71 | 10.08 | 0.59 | |
| (6) | OCH3 | = | = | 7.89 | 2.99 | 8.94 | 7.76 | 0.52 | |
| (7) | OH | Cl | OH | 8.66 | 3.4 | 11.56 | 10.08 | 0.52 | |
| (8) | OCH3 | Cl | OH | 8.32 | 2.17 | 4.71 | 10.08 | 0.54 | |
| (9) | OCH3 | OH top | OH | 7.52 | 3.13 | 9.80 | 10.51 | 1.08 | |
| (10) | OCH3 | OH bottom | OH | 8.19 | 3.13 | 9.80 | 10.51 | 0.64 |