Table 2.

Performance comparisons of DisoFLAG and other predictors on the DP93 independent test dataset

Prediction	Methoda	AUC	AUPR	Fmax	MCC	BACC
Protein binding	DisoFLAG	0.839	0.340	0.434	0.370	0.768
	fIDPnnb	0.817	0.277	0.427	0.357	0.758
	DeepDISOBindb	0.808	0.384	0.438	0.361	0.727
	DisoRDPbindb	0.780	0.243	0.395	0.335	0.752
	ANCHOR-2c	0.741	0.222	0.359	0.277	0.705
	MoRFchibi-Lightb	0.729	0.269	0.311	0.210	0.664
	SPOT-MoRFc	0.721	0.223	0.296	0.207	0.658
	MoRFchibi-Webb	0.688	0.243	0.280	0.173	0.629
DNA binding	DisoFLAG	0.896	0.053	0.152	0.181	0.821
	fIDPnnb	0.812	0.069	0.160	0.161	0.805
	DisoRDPbindb	0.703	0.035	0.125	0.124	0.663
	DeepDISOBindb	0.696	0.010	0.025	0.060	0.689
RNA binding	DisoFLAG	0.908	0.127	0.207	0.222	0.850
	DeepDISOBindb	0.823	0.163	0.338	0.327	0.765
	fIDPnnb	0.816	0.061	0.126	0.190	0.797
	DisoRDPbindb	0.526	0.019	0.044	0.027	0.541
Ion binding	DisoFLAG	0.700	0.013	0.028	0.069	0.695
Lipid binding	DisoFLAG	0.861	0.251	0.304	0.328	0.771
	DisoLipPredb	0.644	0.029	0.070	0.065	0.615
Flexible linker	DisoFLAG	0.897	0.273	0.403	0.389	0.833
	TransDFLc	0.781	0.221	0.206	0.166	0.730
	fIDPnnb	0.712	0.046	0.093	0.102	0.666
	DFLpredb	0.635	0.046	0.095	0.081	0.615

^aThe evaluation results of the comparative methods were calculated based on the results obtained by running their respective web servers^b and standalone packages^c. Predictors in each prediction are sorted by their AUC value