Table 2.
Roles of METTL3 in PCa
| Target | Signaling pathways | Mechanism | Biological functions | Ref. |
|---|---|---|---|---|
| PVT1 | miR-27b-3b/BLM | Enhance expression of PVT1 mRNA | Proliferation of PCa | [142] |
| MALAT | PI3K/AKT | Enhance expression of MALAT mRNA | Proliferation of PCa | [141] |
| KIF6C | IGF2BP3/KIF3C | Enhance KIF6C mRNA stability | Proliferation of PCa | [140] |
| DGCR8 | Wnt/β-catenin | Promote the maturation of pri-miR-182 | Proliferation of PCa | [139] |
| Myc | Activate Myc | Proliferation of PCa | [30] | |
| ARHGDIA | EMT | Migration and invasion | [132] | |
| LEF1 | Wnt/β-catenin | Enhance expression of LEF1 mRNA | Migration and invasion | [128] |
| YTHDF2 | cAMP | Inhibition expression of LHPP mRNA and NEX3–1 mRNA | Migration and invasion | [125] |
| GLI1 | c-Myc/Cyclin D1 | Enhance expression of GLI1 mRNA | Migration and invasion | [29] |
| IGFBP2 | PCAT6/IGF2BP2/IGF1R | Enhance expression of PCAT6 mRNA, Enhance IGF1R stability | Bone metastasis | [93] |
| IGFBP1 | Enhance expression of ITGB1 mRNA | Bone metastasis | [31] | |
| SNHG7 | c-Myc | Enhance SNHG7 mRNA stability, recruit SRSF1 | Glycolysis | [149] |
| NR5A2 | Enhance expression of NR5A2 mRNA | Drug-resistance | [154] |