Table 3.
Reclassification for BWHS predicted 5-year risk versus BWHS + PRS predicted 5-year risk
| Cases | BWHS + PRS | Total | ||
|---|---|---|---|---|
| < 1.66% | 1.66–< 2.5% | ≥ 2.5% | ||
| BWHS model only | ||||
| < 1.66% | 503 | 94 | 23 | 620 |
| 1.66–< 2.5% | 72 | 134 | 74 | 280 |
| ≥ 2.5% | 2 | 8 | 12 | 22 |
| Total | 577 | 236 | 109 | 922 |
| Controls | BWHS + PRS | Total | ||
|---|---|---|---|---|
| < 1.66% | 1.66–< 2.5% | ≥ 2.5% | ||
| BWHS model only | ||||
| < 1.66% | 1146 | 126 | 13 | 1285 |
| 1.66–< 2.5% | 185 | 245 | 106 | 536 |
| ≥ 2.5% | 4 | 9 | 10 | 23 |
| Total | 1335 | 380 | 129 | 1844 |
Net reclassification improvement (95% CI) = 0.092 (0.065–0.119)
For cases, reclassification = 0.118; for controls, reclassification = − 0.026