Table 5.
eQTL results curated from GTEx database for SNPs on of risk alleles of MMP9 gene
| RS ID | R2 | Gene Symbol | Tissue | Effect Size | P |
|---|---|---|---|---|---|
| rs3918251 | 1 | MMP9 | Cells - Cultured fibroblasts | -0.203 | 8.55E-08 |
| rs3918251 | 1 | CD40 | Adipose - Subcutaneous | 0.156 | 1.51E-05 |
| rs3918251 | 1 | MMP9 | Skin - Not Sun Exposed (Suprapubic) | 0.259 | 2.46E-07 |
| rs3918251 | 1 | MMP9 | Skin - Sun Exposed (Lower leg) | 0.182 | 4.12E-05 |
| rs3918251 | 1 | CD40 | Skin - Sun Exposed (Lower leg) | 0.136 | 1.20E-04 |
| rs17577 | 1 | MMP9 | Testis | 0.348 | 8.02E-05 |
| rs3918261 | 1 | MMP9 | Testis | 0.340 | 1.16E-04 |
| rs3918262 | 1 | CD40 | Adipose - Subcutaneous | 0.181 | 2.65E-05 |
| rs3918262 | 1 | CD40 | Skin - Sun Exposed (Lower leg) | 0.177 | 4.05E-05 |
Functional relevance of SNP on gene expression in GTEx database. Significant eQTL results of MMP9 SNPs on the nearby genes were summarized
eQTL Expression quantitative trait loci, Effect size The degree to which an SNP influences the expression of genes in a particular tissue