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. 2024 Jan 2;24:4. doi: 10.1186/s12935-023-03181-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — lncRNA FOXD1-AS1 overexpression promotes pancreatic cancer CSC self-renewal and tumorigenesis. A MIA Paca-2 and AsPC-1 cells were infected with a virus overexpressing lncRNA FOXD1-AS1, and the efficacy of overexpression was subsequently assessed using RT-PCR. B and C RT-PCR analysis was employed to evaluate CD133 and CD90 expression in control PC cells and lncRNA FOXD1-AS1 overexpressing cells. D The study utilized a spheroid formation assay to examine the impact of lncRNA FOXD1-AS1 overexpression on cellular behavior in PC cells, with representative images of spheres shown. E The percentage of pancreatic cancer CSCs in lncRNA FOXD1-AS1 overexpressing and control PC cells, compared using an in vitro limiting dilution assay. F An in vivo limiting dilution assay was conducted on lncRNA FOXD1-AS1 overexpressing and control PC cells. Tumors were monitored over 2 months with n = 5 for each group