Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 2;24:4. doi: 10.1186/s12935-023-03181-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — lncRNA FOXD1-AS1 determines the response to 5-FU in PC cells. A Real-time PCR analysis of lncRNA FOXD1-AS1 5-FU-resistant and control PC cells. B PC cells with lncRNA FOXD1-AS1 knockdown or control were infected with SPP1 overexpression or a negative control virus for 48 h before being treated with 5-FU (10 μM). Flow cytometry was utilized to determine the proportion of apoptotic cells. C The Kaplan–Meier assay was employed to determine the overall survival of PC patients treated with 5-FU in the high lncRNA FOXD1-AS1 (n = 15) or low lncRNA FOXD1-AS1 (n = 15) groups. D PDXs with low lncRNA FOXD1-AS1 levels generated from primary PCs were treated for 24 days with 5-FU or saline (n = 3). The growth rate of the xenograft was determined. E Three groups of PDXs were included in this study. PDXs were derived from primary PCs exhibiting high levels of lncRNA FOXD1-AS1. These PDXs were then treated with either 5-FU or saline for 24 days. Each group consisted of three PDXs, and the rate of xenograft growth was determined