Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 3;26:12. doi: 10.1186/s13075-023-03220-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Bulk RNA sequencing results. A The breakdown of D.E. genes between non-degenerated and degenerated CEP samples is depicted by a volcano plot. Positive F.C. indicates upregulation in degenerated samples, whereas negative F.C. indicates upregulation in non-degenerated samples. Thresholds for upregulation were set at |F.C.| ≥ 1.5 and significance was set at q < 0.05. Boxed numbers indicate number of significantly D.E. genes in each compartment of plot. B The results of the literature review are summarized by a Venn diagram showing the number of genes previously studied in the CEP, the IVD, or cartilage. C Breakdown of the genes previously studied in each tissue of interest. Purple-highlighted genes were previously studied in all three tissues and green-highlighted genes were previously studied in the IVD and cartilage only. F.C., fold change; D.E., differentially expressed