Table 3.

Univariate and multivariate analyses of predictors of overall survival and progression free survival after treatment.

Variable	Overall survival				Progression free survival
	Univariate analysis	Multivariate analysis			Univariate analysis	Multivariate analysis
	p value	Hazard Ratio	95% CI	p value	p value	Hazard Ratio	95% CI	p value
Age (≤ 60/> 60yrs)	0.288				0.182
Gender (Male/Female)	0.432				0.423
Tumor size (≤ 5/> 5cm)	0.735				0.178
Tumor number (1/≥2)	0.898				0.244
Portal vein tumor invasion (I-II/III-IV)	0.567				0.204
ECOG performance status (0/1)	0.109	0.387	0.120-1.248	0.112	0.027	0.397	0.160-0.989	0.047
Child-Pugh class(A/B)	0.505				0.501
α-Fetoprotein (≤ 400/> 400 ug/L)	0.834				0.915
Hepatitis B virus infection (Positive/Negative)	0.262				0.403
Hepatitis C virus infection (Positive/Negative)	0.216				0.999
Treatment allocation (RT-TACE-LEN/TACE-LEN)	0.002	0.529	0.298-0.938	0.029	0.002	0.577	0.364-0.915	0.019

CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; RT, radiation; TACE, trans arterial chemoembolization; LEN, Lenvatinib.