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. 2023 Dec 20;14:1309997. doi: 10.3389/fimmu.2023.1309997

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Copyright © 2023 Akhtar, Islam, Khaton, Soltana, Jafrin, Rahman, Tauheed, Ahmed, Khan, Akter, Khan, Islam, Khanam, Biswas, Ahmmed, Ahmed, Rashid, Hossain, Alam, Alamgir, Rahman, Ryan, Harris, LaRocque, Flora, Chowdhury, Khan, Banu, Shirin, Bhuiyan and Qadri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kinetics of IgG subclasses after receiving COVID-19 mRNA vaccines as both primary and booster. RBD-specific IgG1 (A), IgG2 (B), IgG3 (C) and IgG4 (D) were analyzed in serum samples after four mRNA doses at different time intervals. Different doses of vaccine administration time points are indicated below the graphs. Samples were collected before vaccination (Pre-V), 1 month, 2/3 Months, 6 months, 12 months, 18 months, and 24 months after the first vaccination. Symbols without any color represent participants who got infected before or after vaccination. Statistical analysis was performed between pre and post-vaccination antibody titer using the Kruskal-Wallis test. **P <0.01, ***P <0.001, ns, not significant; P >0.05.