Table 2.
Meta-analysis of risk factors of fertility concerns in breast cancer patients.
| Influencing factors | Combination studies |
Heterogeneity of
study design |
Analysis model | OR (95%CI) | P 2 | Egger’s test | |
|---|---|---|---|---|---|---|---|
| I 2 | P 1 | ||||||
| Full-time work | 2 | 51% | 0.15 | Random | 1.41[1.03,1.93] | 0.03 | NA |
| Age | 4 | 97% | <0.00001 | Random | 0.63[0.14,2.85] | 0.54 | 0.761 |
| Education | 4 | 82% | 0.0007 | Random | 2.65[1.65,5.63] | 0.01 | 0.075 |
| Economic | 3 | 55% | 0.11 | Random | 0.89[0.63,1.26] | 0.51 | 0.536 |
| Fertility intentions | 3 | 88% | 0.0003 | Random | 7.84[1.50,37.40] | 0.01 | 0.815 |
| With partner | 3 | 75% | 0.02 | Random | 0.41[0.33,0.50] | <0.00001 | 0.374 |
| Depression | 2 | 0% | 0.62 | Fixed | 1.25[1.03,1.52] | 0.02 | NA |
| ≥1 child | 4 | 19% | 0.29 | Fixed | 0.3[0.22,0.40] | <0.00001 | 0.273 |
| Surgery | 3 | 71% | 0.03 | Random | 0.72[0.47,1.11] | 0.14 | 0.859 |
| Chemotherapy | 4 | 55% | 0.08 | Random | 1.38[0.96,2.00] | 0.08 | 0.433 |
| Endocrine therapy | 4 | 14% | 0.32 | Fixed | 1.32[1.08,1.62] | 0.008 | 0.225 |
| Genetic | 2 | 0% | 0.92 | Fixed | 1.07[0.71,1.60] | 0.74 | NA |
NA: Insufficient number for Egger’s test.The bold values: Nominal p-value <0.05.