Table 3.
Functions of m6A ‘readers’ in liver cancer
| Regulator | Effect on m6A modification | Expression change | (Refs.) |
|---|---|---|---|
| YTH domain family | |||
| YTHDF1 | Enhances m6A-modified RNA translation | Up | 53,58 |
| YTHDF2 | Promotes m6A-modified RNA degradation | Up | 56,59 |
| YTHDF3 | Accelerates m6A-modified RNA translation and degradation | Up | 56,60 |
| YTHDC1 | Regulates m6A-modified RNA splicing and export | Up | 54 |
| YTHDC2 | Promotes m6A-modified RNA translation efficiency | Up | 53 |
| HNRNP family | |||
| HNRNPC and HNRNPG | Regulates the abundance and alternative splicing of target genes | Up | 61 |
| HNRNPA2B1 | Promotes the processing of primary miRNA | Up | 62,63 |
| IGF2BP1-3 | Stabilizes m6A-modified mRNA | Up | 64,65 |
m6A, N6-methyladenosine; miRNA, microRNA; YTH, YT521-B homology; YTHDF1, YTH domain family 1; YTHDC1, YTH domain containing 1; HNRNP, heterogeneous nuclear ribonucleoprotein protein; IGF2BP, insulin-like growth factor 2 mRNA binding protein