Table 2.

PFP pharmacokinetic parameters in the blood by gender

Pharmacokinetic parameters	Gender	n	Arithmetic mean(standard deviation)	Arithmetic coefficient of variation (%)	Median	Min – Max	Geometric mean	Geometric coefficient of variation (%)
Cmax (uL/mL)	Male	8	0.00035852 (0.000134325)	37.5	0.0003376	0.0001840–0.0005811	0.00033626	40.4
	Female	4	0.00031719 (0.000143485)	45.2	0.00024774	0.0002410–0.0005323	0.00029785	40.3
Tmax (min)	Male	8	2.08 (0.501)	24.1	2.00	1.5–3.0	2.02	23.9
	Female	4	2.03 (0.411)	20.3	2.05	1.5–2.5	1.99	21.4
AUClast ((uL/mL)*min)	Male	8	0.000691 (0.0003440)	49.8	0.000745	0.00024–0.00134	0.00061	61.3
	Female	4	0.000575 (0.0002464)	42.8	0.000505	0.00036–0.00093	0.000541	41.1
AUC∞ ((uL/mL)*min)	Male	6	0.001143 (0.0003185)	27.9	0.00105	0.00090–0.00178	0.001114	24.2
	Female	4	0.000913 (0.0003235)	35.4	0.00079	0.00068–0.00139	0.000876	32.5
t1/2 (min)	Male	6	1.63 (0.308)	18.8	1.60	1.2–2.1	1.61	19.3
	Female	4	1.75 (0.387)	22.1	1.65	1.4–2.3	1.72	21.2
CL (L/hr)	Male	6	5289.987 (1205.885)	22.8	5624.865	3062.01–6418.42	5148.346	27.5
	Female	4	5553.425 (1626.382)	29.3	5928.34	3295.51–7061.51	5342.39	34.6
Vss (L)	Male	6	308.275 (97.835)	31.7	283.3	214.34–467.41	296.335	31.1
	Female	4	324.618 (88.747)	27.3	361.225	192.68–383.34	313.297	33.4