Table 3.
Calculation result of PFP pharmacokinetic parameters in expired air
| Pharmacokinetic Parameters | n | Arithmetic mean(SD) | Coefficient of variation of arithmetic mean (%) | Median | Min – max | Geometric mean | Coefficient of variation of geometric mean (%) |
|---|---|---|---|---|---|---|---|
| Ae0 − 5 (uL) | 12 | 30.455 (18.668) | 61.3 | 24.18 | 8.932–63.669 | 25.25 | 73.4 |
| Ae0 − 15.5 (uL) | 12 | 42.041 (24.631) | 58.6 | 34.09 | 13.887–83.565 | 35.25 | 70.9 |
| Ae0 − tlast (uL) | 11 | 25.039 (15.246) | 60.9 | 21.05 | 7.607–50.920 | 20.70 | 74.9 |
| Ae∞(uL) | 12 | 44.997 (26.010) | 57.8 | 36.89 | 15.401–90.499 | 38.01 | 68.7 |
| CLlung (L/hr) | 12 | 3203.8 (2407.95) | 75.2 | 2416.50 | 982–7978 | 2501.50 | 84.2 |
| PFP excretion rate1 (%) | 12 | 47.89 (30.523) | 63.7 | 34.80 | 15.1–103.7 | 39.42 | 74.3 |
| PFP excretion rate2 (%) | 12 | 64.45 (41.069) | 63.7 | 46.85 | 20.4–139.5 | 53.06 | 74.3 |
| PFP excretion rate3 (%) | 12 | 38.33 (24.436) | 63.8 | 27.85 | 12.1–83.0 | 31.54 | 74.3 |
Note: PFP excretion rate: Cumulative excretion volume of PFP (0-15.5 min) in the expired air ÷ PFP dose