Table 1.

Genes differentially regulated in all three M1_globalrofAKO strains compared with isogenic parent M1_global strains

Gene ID	Gene name	Description	H1488		H1489		H1499
			log2fold change	P adj	log2fold change	P adj	log2fold change	P adj
Spy0106	rofA	Transcriptional regulator	−11.241	<0.001	−13.902	<0.001	−13.938	<0.001
Spy0107	na	–	−3.388	<0.001	−3.747	<0.001	−3.816	<0.001
Spy0108	na	Signal peptidase I	−3.348	<0.001	−3.510	<0.001	−3.952	<0.001
Spy0109	na	–	−3.288	<0.001	−3.514	<0.001	−3.983	<0.001
Spy0110	eftLSL	Putative exported protein	−3.478	<0.001	−3.399	<0.001	−4.363	<0.001
Spy0111	na	Hypothetical protein	−3.406	<0.001	−3.596	<0.001	−4.044	<0.001
Spy0113	na	Transposase	−2.674	<0.001	−2.463	0.001	−1.153	<0.001
Spy0114	na	Sortase	−2.248	<0.001	−1.710	<0.001	−0.612	0.002
Spy0212	na	N-Acetylmannosamine-6-phosphate 2-epimerase	0.723	0.002	1.855	0.001	1.417	<0.001
Spy0213	na	N-Acetylneuraminate-binding protein	0.812	0.002	1.936	0.026	1.506	<0.001
Spy1081	na	PTS system, cellobiose-specific IIA component	−0.755	0.019	−0.952	0.010	−1.270	<0.001
Spy1281	na	Two-component response regulator	−0.601	0.010	−0.579	0.031	−0.601	<0.001
Spy1453	na	Phage protein	−0.694	0.005	−0.676	0.033	−0.804	<0.001
Spy1715	scpA	C5A peptidase precursor	0.589	0.003	2.323	<0.001	0.510	0.010

na, Not applicable.

Mapping of transcripts used the MGAS5005 (CP000017) reference genome