Table 3.
Functional category enrichments for DEGs from Auts2-ex7−/− P0 forebrain and P14 hippocampus.
| Enrichment −logP | |||||
|---|---|---|---|---|---|
| ex7−/− | Nes-cre, ex7−/− | ||||
| P0 FB | P14HC | ||||
| Functional category | up | down | up | down | |
| GOBP | Positive regulation of transcription by RNA polymerase II | 10 | - | - | - |
| GOBP | Pallium development | 10 | - | - | - |
| MGI | Decreased brain size | 5.25 | - | - | - |
| GOBP | Forebrain development | 10 | - | 10 | 4.97 |
| GOBP | Axonogenesis | 10 | - | 10 | - |
| GOBP | Synapse organization | 10 | - | 10 | - |
| GOBP | Synapse organization | 10 | - | 10 | - |
| MGI | Abnormal motor learning | 10 | - | 10 | - |
| GOBP | Calcium-ion regulated exocytosis | 5.82 | - | 10 | - |
| GOBP | chemotaxis | 5.85 | - | - | 5.32 |
| GOMF | Glutamate receptor activity | - | 10 | - | - |
| GOBP | Positive regulation of synaptic transmission | - | 10 | - | - |
| GOBP | Actin filament-based process | - | 10 | - | - |
| GOCC | Postsynaptic density | - | 10 | - | - |
| MGI | Abnormal emotion/affect behavior | - | 10 | - | - |
| MGI | Abnormal excitatory postsynaptic currents | - | 10 | - | - |
| PATH | KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | - | 10 | - | - |
| MGI | Abnormal brain interneuron morphology | - | 5.09 | - | - |
| MGI | Abnormal cognition | - | 10 | 10 | - |
| GOMF | Ion channel activity | - | 10 | 5.2 | - |
| PATH | KEGG_CALCIUM_SIGNALING_PATHWAY | - | 10 | 5.2 | |
| GOCC | Postsynaptic membrane | - | 10 | 4.56 | - |
| GOBP | Secretion by cell | - | 10 | 5.78 | - |
| GOMF | Gated channel activity | - | 4.66 | 4.52 | - |
| GOCC | Dendritic shaft | - | 4.63 | 4.22 | - |
| GOBP | Regulation of neurotransmitter transport | - | - | 10 | - |
| GOBP | Dendrite development | - | - | 10 | - |
| GOBP | Adenylate cyclase-activating G protein-coupled receptor signaling pathway | - | - | 10 | - |
| GOBP | Positive regulation of cell migration | - | - | - | 10 |
| GOBP | glial cell differentiation | - | - | - | 10 |
| GOBP | Regulation of neurogenesis | - | - | - | 10 |
| GOBP | Regulation of neuron differentiation | - | - | - | 10 |
| MGI | Abnormal dentate gyrus morphology | - | - | - | 10 |
| GOCC | Hippocampal mossy fiber to CA3 synapse | - | - | - | 10 |
| GOBP | Regulation of neurogenesis | - | - | - | 5.90 |
Functional enrichments were determined for up- and down-regulated FDR< 0.05 DEGs from comparisons of ex7−/− mutant P0 FB (forebrain) and Nes-cre, ex7−/− P14 HC (hippocampus) to WT littermates using the ToppCluster Suite (Kaimal et al. 2010). Representative and most descriptive terms for the most highly enriched categories are shown for each comparison, highlighting categories that are shared by, or differentially regulated in the P0 and P14 samples. In the ToppCluster output, all categories with −logP ≥ 10 are listed with a value of 10 (in columns 3–6). GOBP, GO biological process; GOMF, GO molecular function; GOCC, GO cellular component; PATH, pathways; MGI, mouse genome informatics Mouse Phenotypes.