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. Author manuscript; available in PMC: 2024 Jan 3.
Published in final edited form as: Brain Res. 2021 Nov 10;1774:147721. doi: 10.1016/j.brainres.2021.147721

Fig. 1.

Fig. 1.

Characterization of magnitude and duration of bilateral allodynia in TRPV1(−/−) knockout (KO), (+/−) heterozygous (HET), and (+/+) wildtype (WT) mice. A, B, Mice develop and maintain CCI-induced ipsilateral and contralateral allodynia regardless of functional TRPV1 copy number. Before surgical manipulation, all experimental groups exhibited similar ipsilateral and contralateral hindpaw BL thresholds. Unilateral CCI surgery produced significant bilateral allodynia at Day 1 post CCI through Day 27 post CCI compared to sham mice. Data reflect mean ± SEM, n = 6 mice/group.