Intrathecal AM1710 reversal of allodynia requires CB2R actions A, B, Intrathecal pre-treatment with the CB2R selective antagonist AM630, but not the CB1R antagonist AM251, blocks the bilateral reversal of allodynia by AM1710 in TRPV1(−/−) mice. ****p < 0.0001, vs. time matched CCI Vehicle-injected control (Tukey’s test), and results are mean ± S.E.M, n = 3 mice/group.