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. 2024 Jan 2;25:3. doi: 10.1186/s13059-023-03126-1

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Fig. 3 — Variants identified from massively parallel reporter assays (MPRAs) are overrepresented in top FORGEdb scores. Shown here are (A) the number of expression-modulating variants (emVars) per 1000 SNPs (divisor, y-axis) for each FORGEdb score bin (0–10) (x-axis), (B) a histogram of FORGEdb scores for emVars (orange) and 37 million SNPs available in FORGEdb (blue), (C) a histogram of FORGEdb scores for p < 0.001 MPRA variants from Kircher et al. (orange) and 37 million SNPs available in FORGEdb (blue), (D) a bar chart of FORGEdb scores (orange) and RegulomeDB (RDB) scores for p < 0.000001 emVars (blue), and (E) a bar chart of FORGEdb scores (orange) and RegulomeDB scores for p < 0.05 MPRA variants for which both a FORGEdb score and a RegulomeDB score is available from Kircher et al. (blue)