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. 2024 Jan 2;24:14. doi: 10.1186/s12885-023-11703-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The expression and characteristics of hsa_circ_001726 in HCC. A Volcano Plot showing the differentially expressed circRNAs between adjacent nontumor tissues and tumor tissues without metastasis. B Volcano Plot showing the differentially expressed circRNAs between tumor tissues without metastasis and tumor tissues with metastasis. C The intersection of differentially expressed circRNAs. D Heatmap showing the 11 overlapping differentially expressed circRNAs. E The expression of CCT2 in tumor and normal tissues from TCGA-LIHC cohort. F Kaplan–Meier curves analyzed the connection between CCT2 expression and overall survival of HCC patients in TCGA-LIHC cohort. G QRT-PCR detected the expression of CCT2 and hsa_circ_001726 in Huh7 cells following RNase R treatment. H QRT-PCR examined the expression of CCT2 and hsa_circ_001726 in Huh7 cells following Actinomycin D treatment. I QRT-PCR assessed the expression of CCT2 and hsa_circ_001726 in nuclear and cytoplasm of Huh7 cells. J RNA-FISH assay identified the localization of hsa_circ_001726 in Huh7 cells. ^**P < 0.01, ^***P < 0.001 vs Mock, CCT2 group