Table 1.
Demographic data of the patients in the study.
n | 240 week | 250–260–7 weeks | 270–280–7weeks | 290–300–7 weeks | 310–320–7 weeks | 330–340–7 weeks | 350–7 week | p | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | n | % | n | % | n | % | n | % | n | % | n | % | ||||
Antenatal steroid administration | None/Unknown (n=207) | 0 | 0.0 | 12 | 20.0 | 11 | 16.4 | 38 | 31.7 | 44 | 27.8 | 78 | 37.1 | 24 | 38.1 | 0.005 |
One dose (n=170) | 1 | 33.3 | 22 | 36.7 | 13 | 19.4 | 23 | 19.2 | 41 | 25.9 | 53c | 25.2 | 17c | 27.0 | ||
Two doses (n=304) | 2 | 66.7 | 26 | 43.3 | 43 | 64.2 | 59 | 49.2 | 73 | 46.2 | 79c | 37.6 | 22c | 34.9 | ||
Mode of delivery | Vaginal Delivery (n=35) | 0 | 0.0 | 3 | 5.0 | 1 | 1.5 | 5 | 4.2 | 13 | 8.2 | 13 | 6.2 | 0e,f | 0.0 | 0.046 |
Cesarean (n=646) | 3 | 100.0 | 57 | 95.0 | 66 | 98.5 | 115 | 95.8 | 145 | 91.8 | 197 | 93.8 | 63e,f | 100.0 | ||
Resuscitation requirement | None (n=58) | 0 | 0.0 | 2 | 3.3 | 0 | 0.0 | 8 | 6.7 | 13 | 8.2 | 25 | 11.9 | 10c | 15.9 | <0.001 |
‘’PBV-t piece (n=525) | 0 | 0.0 | 31 | 51.7 | 40 | 59.7 | 94a,b | 78.3 | 135 a,b | 85.4 | 175 a,b | 83.3 | 50 a,b | 79.4 | ||
Intubation (n=98) | 3 | 100.0 | 27 | 45.0 | 27 | 40.3 | 18 a,b,c | 15.0 | 10 a,b,c | 6.3 | 10 a,b,c,d | 4.8 | 3 a,b,c | 4.8 | ||
Sex | Female (n=58) | 2 | 66.7 | 34 | 56.7 | 28 | 41.8 | 69 | 57.5 | 58d | 36.7 | 98 | 46.7 | 32 | 50.8 | 0.015 |
Male (n=360) | 1 | 33.3 | 26 | 43.3 | 39 | 58.2 | 51 | 42.5 | 100 d | 63.3 | 112 | 53.3 | 31 | 49.2 | ||
SIMV-PS-VG* | Available (n=152) | 3 | 100.0 | 38 | 63.3 | 42 | 62.7 | 29b,c | 24.2 | 19 b,c | 12.0 | 16 b,c,d | 7.6 | 5 b,c | 7.9 | <0.001 |
None (n=529) | 0 | 0.0 | 22 | 36.7 | 25 | 37.3 | 91 b,c | 75.8 | 139 b,c | 88.0 | 194 b,c,d | 92.4 | 58 b,c | 92.1 | ||
HFO Ɨ | Available (n=62) | 2 | 66.7 | 20 | 33.3 | 13 | 19.4 | 14b | 11.7 | 4a,b,c,d | 2.5 | 7 a,b,c | 3.3 | 2 a,b | 3.2 | <0.001 |
None (n=619) | 1 | 33.3 | 40 | 66.7 | 54 | 80.6 | 106b | 88.3 | 154 a,b,c,d | 97.5 | 203 a,b,c | 96.7 | 61 a,b | 96.8 | ||
Surfactant administration | Available (n=151) | 3 | 100.0 | 38 | 63.3 | 42 | 62.7 | 36b,c | 30.0 | 13 b,c,d | 8.2 | 15 b,c,d | 7.1 | 4 b,c,d | 6.3 | <0.001 |
None (n=530) | 0 | 0.0 | 22 | 36.7 | 25 | 37.3 | 84 b,c | 70.0 | 145 b,c,d | 91.8 | 195 b,c,d | 92.9 | 59b,c,d | 93.7 | ||
Surfactant administration dose | One dose (n=87) | 2 | 66.7 | 17 | 44.7 | 22 | 52.4 | 23 | 63.9 | 9 | 69.2 | 10 | 66.7 | 4 | 100.0 | 0.246 |
Two doses (n=64) | 1 | 33.3 | 21 | 55.3 | 20 | 47.6 | 13 | 36.1 | 4 | 30.8 | 5 | 33.3 | 0 | 0.0 | ||
Necrotizing enterocolitis | None (n=670) | 3 | 100.0 | 56 | 93.3 | 66 | 98.5 | 117 | 97.5 | 157 | 99.4 | 208 | 99.0 | 63 | 100.0 | 0.124 |
Stage 2 and Stage 3 NEC (n=11) | 0 | 0.0 | 4 | 6.7 | 1 | 1.5 | 3 | 2.5 | 1 | 0.6 | 2 | 1.0 | 0 | 0.0 | ||
Bronchopulmonary Dysplasia(BPD) | Available (n=60) | 3 | 100.0 | 31 | 51.7 | 17b | 25.4 | 5a,b,d | 4.2 | 4 a,b,d | 2.5 | 0 a,b,d | 0.0 | 0 a,b,d | 0.0 | <0.001 |
None (n=621) | 0 | 0.0 | 29 | 48.3 | 50b | 74.6 | 115 a,b,d | 95.8 | 154 a,b,d | 97.5 | 210 a,b,d | 100.0 | 63 a,b,d | 100.0 | ||
Number of dexamethasone-furosemide treatment/cures for BPD | No cure (n=632) | 0 | 0.0 | 33a | 55.0 | 54a,b | 80.6 | 117a,b, c | 97.5 | 156a,b,c | 98.7 | 209a,b, c | 99.5 | 63a,b,c | 100.0 | <0.001 |
Single cure(n=42) | 2 | 66.7 | 24 | 40.0 | 11 | 16.4 | 3 a,b,c | 2.5 | 1 a,b,c | 0.6 | 1 a,b,c | 0.5 | 0 a,b,c | 0.0 | ||
Two cure (n=7) | 1 | 33.3 | 3 | 5.0 | 2 | 3.0 | 0a,b | 0.0 | 1a,b | 0.6 | 0a,b | 0.0 | 0a,b | 0.0 | ||
Retinopathy of Prematurity | None (n=666) | 2 | 66.7 | 50 | 83.3 | 65 | 97.0 | 118b,c | 98.3 | 158 b,c | 100.0 | 210 b,c | 100.0 | 63 b,c | 100.0 | <0.001 |
¥VEGF (n=8) | 0 | 0.0 | 4 | 6.7 | 2 | 3.0 | 2 | 1.7 | 0b | 0.0 | 0b | 0.0 | 0b | 0.0 | ||
Laser (n=7) | 1 | 33.3 | 6 | 10.0 | 0a,b | 0.0 | 0 a,b | 0.0 | 0 a,b | 0.0 | 0 a,b | 0.0 | 0 a,b | 0.0 | ||
Intracranial hemorrhage | None (n=661) | 0 | 0.0 | 55a | 91.7 | 61 a,b | 91.0 | 116 a,b | 96.7 | 157 a,b | 99.4 | 209 a,b | 99.5 | 63 a,b | 100.0 | <0.001 |
Stage 2 and/or 3 hemorrhage (n=20) | 3 | 100.0 | 5a | 8.3 | 6 a,b | 9.0 | 4 a,b | 3.3 | 1 a,b | 0.6 | 1 a,b | 0.5 | 0 a,b | 0.0 | ||
clinical/proven sepsis | None (n=513) | 0 | 0.0 | 22 | 36.7 | 37 | 55.2 | 78a,b | 65.0 | 139a,b,c | 88.0 | 183a,b,c | 87.1 | 54a,b | <0.001 | |
clinical/proven sepsis (n=168) | 3 | 100.0 | 38 | 63.3 | 30 | 44.8 | 42a,b | 35.0 | 19a,b,c | 12.0 | 27a,b,c | 12.9 | 9a,b |
“PBV: Positive pressure ventilation,
SIMV-VG-PSV; Synchronous intermittent mechanical ventilation + volume guarantee + pressure support ventilation,
HFO: High frequency oscillation,
VEGF; vascular endothelial growth factor; It shows the differences with
24,
25–26,
27–28,
29–30,
31–32 and
33–34 weeks.