Table 2.
Simple and multivariable conditional logistic regression models of spirometrically defined chronic obstructive pulmonary disease (COPDspiro, n = 504) and asthma COPD overlap subgroup(ACOspiro, n = 244) vs. early arrival (within 48 h) at the World Trade Center (WTC) disaster site in a 1:4 nested case–control study of WTC rescue and recovery workers, matched on age (within 2 years), sex, and height (within 5 cm)
| Variable | Value | COPDspiro | ACOspiro | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| OR | 95% CI | ORadj | 95% CI | OR | 95% CI | ORadj | 95% CI | ||
| Arrival at WTC disaster site | ≤48 h | 1.09 | 0.86, 1.38 | 1.34 | 1.01, 1.78 | 1.21 | 0.85, 1.72 | 1.55 | 1.04, 2.32 |
| > 48 h | Ref | Ref | Ref | Ref | |||||
| Body mass index category | Normal | Ref | Ref | Ref | Ref | ||||
| Overweight | 0.6 | 0.42, 0.86 | 0.73 | 0.48, 1.09 | 0.8 | 0.50, 1.28 | 0.87 | 0.52, 1.46 | |
| Obese | 0.74 | 0.53, 1.02 | 0.87 | 0.6, 1.25 | 1.16 | 0.72, 1.86 | 1.22 | 0.72, 2.07 | |
| Cohort entry period | 2009+ | ref | Ref | Ref | Ref | ||||
| 2006–2008 | 1.54 | 1.12, 2.13 | 1.38 | 0.95, 1.98 | 1.75 | 1.06, 2.90 | 1.5 | 0.86, 2.59 | |
| 2002–2005 | 2.42 | 1.84, 3.20 | 1.76 | 1.26, 2.46 | 2.9 | 1.84, 4.57 | 2.14 | 1.27, 3.60 | |
| Smoking intensity | Pack-year | 1.06 | 1.04, 1.07 | 1.05 | 1.04, 1.07 | 1.05 | 1.03, 1.06 | 1.04 | 1.03, 1.06 |
| Former smoking status | No | Ref | Ref | Ref | Ref | ||||
| Yes | 1.42 | 1.12, 1.80 | 0.84 | 0.63, 1.12 | 1.51 | 1.08, 2.11 | 0.97 | 0.63, 1.50 | |
| Pre-WTC occupation group | Protective | ref | ref | ref | ref | ||||
| BCM&IRG† | 2.65 | 1.76, 4.00 | 2.16 | 1.36, 3.45 | 2.35 | 1.34, 4.12 | 2.17 | 1.14, 4.14 | |
| Other | 3.46 | 2.49, 4.81 | 2.97 | 2.09, 4.22 | 2.93 | 1.92, 4.47 | 2.77 | 1.74, 4.42 | |
| Construction | 2.63 | 1.96, 3.54 | 2.03 | 1.42, 2.91 | 2.49 | 1.58, 3.93 | 1.99 | 1.17, 3.39 | |
| Metabolic syndrome criteria | 0–1 criteria | Ref | Ref | Ref | Ref | ||||
| 2–4 criteria | 1.24 | 0.89, 1.75 | 1.2 | 0.79, 1.84 | 1.37 | 0.84, 2.23 | 1.16 | 0.65, 2.07 | |
| Blood eosinophil count | ≤ 300/mcl | Ref | Ref | Ref | Ref | ||||
| > 300/mcl | 1.65 | 1.25, 2.17 | 1.56 | 1.13, 2.17 | 2.22 | 1.52, 3.24 | 2.15 | 1.43, 3.23 | |
| Blood neutrophil count | ≤ 6000/mcl | Ref | Ref | Ref | Ref | ||||
| > 6000/mcl | 1.5 | 1.15, 1.96 | 1.09 | 0.8, 1.48 | 1.6 | 1.13, 2.27 | 1.2 | 0.81, 1.76 | |
The two multivariable models were adjusted for all the listed covariates
†
BCM&IRG: buildings and grounds cleaning and maintenance, and electrical, telecommunications and other installation and repair groups.