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. 2020 Nov 13;6(46):eaba5723. doi: 10.1126/sciadv.aba5723

Fig. 3. Generation of osteoinductive cytokines by macrophages.

Fig. 3

(A) Expression change of the singled-out chemokines, cytokines, and growth factors between Ti and L. casei-AHT-Ti. (B) Expression of genes related to the production of OSM including CD14 (lipopolysaccharide receptor), COX2, and EPR. (C) Protein levels of CD14, COX2, PGE2, EPR, OSM, IL-6, TNF-α, IL-1β, and IL-10 were further quantified by ELISA assay. (D) Complete process of macrophage activated by L. casei-AHT-Ti for further stimulating osteogenesis. n = 3 independent experiments per group, Ti versus L. casei-AHT-Ti, *P < 0.05, **P < 0.01, and ***P < 0.001. IFN, interferon.