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. Author manuscript; available in PMC: 2024 Jan 3.
Published in final edited form as: Gene. 2018 Apr 25;665:6–17. doi: 10.1016/j.gene.2018.04.065

Fig. 4.

Fig. 4.

HBS1L – MYB intergenic region on chromosome 6q23 with the 2 enhancer sites encompassing the SNPs associated with fetal hemoglobin levels in adults. Schematic structure (not to scale) of HBS1L and MYB region is depicted. The transcription direction of HBS1L and MYB are indicated with black arrows. The peaks at −84 and − 71 are from transcription factor (as indicated) binding data (Stadhouders et al., 2014). The zoomed in parts show DNA sequence at −84 and − 71 upstream of the transcription start site of MYB. The consensus sequences for TAL1 and GATA1 are labeled and boxed. The three SNPs associated with fetal hemoglobin levels in adults are indicated. The green arrow shows the interactions between the enhancers and proximal promoter.