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. 2023 Dec 12;69:102985. doi: 10.1016/j.redox.2023.102985

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Association between SLC39A8 expression and ferroptosis NESs in circulating monocytes in sepsis.

a. The top six pathways with higher NESs in monocytes of the SLC39A8 high-expression group. b. Heatmap of the landscape of ferroptosis NESs of the SLC39A8 high-expression and low-expression groups. c. Distribution of the NESs of ferroptosis exhibited an increase of ferroptosis1/2/4 NESs in the SLC39A8 high-expression group compared to the SLC39A8 low-expression group. d. Correlation analysis revealed a strong relationship between the expression of SLC39A8 and NESs of ferroptosis1/2/4. Two-tailed Student's t-test was performed in c. Pearson correlation analysis was performed in d. ^nsp > 0.05, ****p < 0.0001. Abbreviations: HC: healthy control, S: septic patient, NES: normalized enrichment score.