Fig. 4.

ZIP8 is upregulated in monocytes subjected to ferroptosis from mice treated with CLP.

a-h. Quantification of ZIP8 (a, b), GPX4 (c, d), FTH1 (e, f), and xCT (g, h) in circulating CD45^high/CD11b^high/Ly6G^nega-int monocytes isolated from 8 to 10 weeks old male C57BL/6 mice at 24 h (a, c, e, g) and 48 h (b, d, f, h) post-CLP treatment (n = 5/group). Two-tailed Student's t-test was performed in a-h. **p < 0.01, ***p < 0.001, ****p < 0.0001. Abbreviations: CLP: cecal ligation and puncture, MFI: mean fluorescence intensity.