Table 1:
Patient and Tumor Characteristics According to Treatment Cohort
| Cohort 1 (N=123) n (%) |
Cohort 2 (N=51) n (%) |
Cohort 3 (N=27) n (%) |
P value | |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| <18 months | 26 (21.5) | 3 (5.9) | 0 (0) | 0.002 |
| ≥18 months | 95 (78.5) | 48 (94.1) | 27 (100) | |
| Unknown | 2 | 0 | 0 | |
| Sex | ||||
| Male | 81 (65.8) | 31 (60.8) | 11 (40.7) | 0.053 |
| Female | 42 (34.2) | 20 (39.2) | 16 (59.3) | |
| INSS Stage | ||||
| 4 | 110 (89.4) | 51 (100) | 27 (100) | 0.028 |
| 3 | 12 (9.8) | 0 (0) | 0 (0) | |
| 2b | 1 (0.8) | 0 (0) | 0 (0) | |
| MYCN status | ||||
| Non-Amplified | 63 (58.9) | 32 (72.7) | 23 (88.5) | 0.008 |
| Amplified | 44 (41.1) | 12 (27.3) | 3 (11.5) | |
| Unknown | 16 | 7 | 1 | |
| Histology | ||||
| Favorable | 6 (5.9) | 1 (2.4) | 3 (13.0) | 0.23 |
| Unfavorable | 95 (94.1) | 40 (97.6) | 20 (87.0) | |
| Unknown | 22 | 10 | 4 | |
| Ploidy | 0.77 | |||
| Hyperdiploid | 34 (58.6) | 13 (59.1) | 9 (69.2) | |
| Diploid | 24 (41.4) | 9 (40.9) | 4 (30.8) | |
| Unknown | 65 | 29 | 14 | |
| Number of ASCT | 0.81* | |||
| 1 | 80 (65) | 33 (64.7) | 0 | |
| 2 | 42 (34.2) | 18 (35.3) | 0 | |
| >2 | 1 (0.8) | 0 (0) | 0 |
Abbreviations: ASCT, autologous stem cell transplantation; INSS, International Neuroblastoma Staging System.
*
p-value calculated for Cohort 1 compared to Cohort 2