Table 6.
Independent factors of clinicopathological features on poor overall survival
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | P | 95% CI | HR | P | 95% CI | |
| All cases (n = 152) | ||||||
| Age, ≥ 70 | 1.468 | 0.215 | 0.800–2.694 | 1.483 | 0.235 | 0.774–2.843 |
| Neoadjuvant chemotherapy, + | 3.059 | 0.001 | 1.607–5.824 | 1.464 | 0.331 | 0.679–3.157 |
| Transthoracic approach, Thoracotomy | 1.182 | 0.635 | 0.593–2.354 | 1.009 | 0.982 | 0.485–2.098 |
| Postoperative pneumonia, + | 1.687 | 0.138 | 0.845–3.371 | 1.808 | 0.146 | 0.813–4.020 |
| Anastomotic leakage, + | 1.169 | 0.724 | 0.491–2.779 | 1.381 | 0.497 | 0.543–3.512 |
| Diarrhea during EF | 2.657 | 0.002 | 1.433–4.925 | 2.174 | 0.040 | 1.038–4.456 |
| Pathological stage, ≥ III | 5.235 | < 0.001 | 2.478–11.057 | 4.172 | 0.001 | 1.749–9.947 |
| POM1 PNI, < median (43.4) | 1.037 | 0.907 | 0.565–1.903 | 0.655 | 0.269 | 0.411–1.842 |
| POM1 NLR, < median (2.85) | 1.155 | 0.742 | 0.490–2.723 | 0.870 | 0.716 | 0.411–1.842 |
| POM1 CRP, positive | 1.232 | 0.503 | 0.669–2.271 | 0.887 | 0.742 | 0.435–1.808 |
| Younger patients (n = 80) | ||||||
| Neoadjuvant chemotherapy, + | 3.332 | 0.014 | 1.277–8.692 | 1.358 | 0.614 | 0.413–4.459 |
| Transthoracic approach, Thoracotomy | 1.795 | 0.231 | 0.689–4.680 | 1.195 | 0.749 | 0.400–3.572 |
| Postoperative pneumonia, + | 1.412 | 0.505 | 0.512–3.891 | 2.541 | 0.148 | 0.719–8.980 |
| Anastomotic leakage, + | 2.043 | 0.202 | 0.681–6.123 | 2.721 | 0.147 | 0.704–10.513 |
| Diarrhea during EF | 1.743 | 0.224 | 0.711–4.270 | 0.945 | 0.925 | 0.293–3.054 |
| Pathological stage, ≥ III | 4.656 | 0.003 | 1.689–12.836 | 4.732 | 0.017 | 1.323–16.929 |
| POM1 PNI, < median (43.4) | 1.212 | 0.671 | 0.499–2.939 | 0.323 | 0.056 | 0.101–1.208 |
| POM1 NLR, < median (2.85) | 1.529 | 0.352 | 0.625–3.744 | 1.851 | 0.252 | 0.646–5.300 |
| POM1 CRP, positive | 1.092 | 0.851 | 0.436–2.738 | 0.892 | 0.826 | 0.322–2.469 |
| Elderly patients (n = 72) | ||||||
| Neoadjuvant chemotherapy, + | 2.766 | 0.024 | 1.145–6.679 | 1.076 | 0.903 | 0.334–3.467 |
| Transthoracic approach, Thoracotomy | 0.617 | 0.385 | 0.207–1.835 | 0.719 | 0.613 | 0.200–2.586 |
| Postoperative pneumonia, + | 2.125 | 0.122 | 0.818–5.519 | 2.375 | 0.210 | 0.614–9.185 |
| Anastomotic leakage, + | 0.554 | 0.428 | 0.128–2.386 | 0.802 | 0.783 | 0.167–3.852 |
| Diarrhea during EF | 4.369 | 0.001 | 1.814–10.526 | 3.717 | 0.040 | 1.059–13.042 |
| Pathological stage, ≥ III | 5.590 | 0.002 | 1.834–17.035 | 5.698 | 0.016 | 1.391–23.335 |
| POM1 PNI, < median (43.4) | 0.883 | 0.782 | 0.367–2.123 | 1.245 | 0.775 | 0.315–4.916 |
| POM1 NLR, < median (2.85) | 1.155 | 0.742 | 0.490–2.723 | 0.392 | 0.163 | 0.105–1.461 |
| POM1 CRP, positive | 1.359 | 0.484 | 0.576–3.205 | 0.818 | 0.754 | 0.233–2.875 |
HR hazard ratio, CI confidence interval, EF enteral feeding, POM post-operative month, PNI prognostic nutritional index, NLR neutrophil-to-lymphocyte ratio, CRP C-reactive protein