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. 2024 Jan 4;5:3. doi: 10.1186/s43556-023-00161-z

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© The Author(s) 2024, modified publication 2026

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Fig. 2 — DOT1L is involved in process of PTK binding, growth factor activity and ECM structural constituent in peritoneal mesothelial cells. a 2 ng/ml TGF-β1-stimulated HPMCs with or without 10μM EPZ5676 treatment. b Cell lysates were subjected to immunoblotting analysis with antibodies against α-SMA, fibronectin and GAPDH. c Expression levels of α-SMA and fibronectin were quantified by densitometry and normalized with GAPDH. d Cell lysates were subjected to RNA-sequencing. Volcano plot of RNAs from TGF-β1-injured HPMCs treated with or without EPZ5676. The red or blue dots represented RNAs in HPMCs that are up-regulated or down-regulated, respectively. e Heat map showed differential expressed genes in each group with three repeats. Differential gene expression was displayed as Z-score. f Correlation heat map showed the correlation between differential expressed genes. Red represented positive correlation and blue represented negative correlation. g KEGG analysis for the genes with altered RNA expressions in the cluster bar graph. GO analysis for the genes with altered RNA expressions in the cluster bar graph. h GSEA plots for the gene enrichment with altered RNA expressions based on GO database