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. 2024 Jan 4;5:3. doi: 10.1186/s43556-023-00161-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — DOT1L is involved in process of PTK binding and ECM structural constituent in peritoneal tissues. a Proteomic analysis was carried out in the peritoneum from PDF-injured mice with or without EPZ5676 treatment. b Volcano plot of peritoneal protein from PDF-injured mice treated with or without EPZ5676. The red or blue dots represented proteins in peritoneum that are up-regulated or down-regulated, respectively. c Bubble graph showed the enrichment of genes with altered protein expressions based on GO database. d GSEA plots for the gene enrichment with altered protein expressions based on GO database. e Dot plots showed the expression of FN, COL1A1, CLO4A1, CDH1 and TJP2. f Venn plots showed the number of genes with altered protein and RNA in two enrichments. There were 3 samples in each group