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. 2024 Jan 3;15:216. doi: 10.1038/s41467-023-44090-5

Fig. 5. Circulating fibroblast growth factor 21 expression.

Fig. 5

Circulating fibroblast growth factor 21 (FGF21) NPX (Normalized protein expression): Shown are FGF21 NPX values from samples collected during the first 28 days of hospital admission by four PRO clusters, minimal deficit (MIN, n = 716), physical predominant (PHY, n = 189), deficit, mental/cognitive predominant (COG, n = 210) and deficit, multidomain (MLT, n = 139). Shown are median values (horizontal lines), interquartile ranges (boxes), and 1.5 IQR (whiskers), as well as all individual points. The generalized additive model (GAM) identified a significant difference in FGF21 expression level in association with convalescent cluster groups (adj. p = 0.0135). The four clusters are the following in gray: minimal deficit (MIN), in blue: deficit, physical predominant (PHY), in yellow: deficit, mental/cognitive predominant (COG), and in red: deficit, multidomain (MLT). Statistical differences were determined from generalized linear mixed effects models adjusting for age, sex, participant, and enrollment site. P values were adjusted using the Benjamini–Hochberg method to account for multiple comparisons. See Methods for more details.