Table 1.
Characteristic of included studies.*.
| Citation | Participants (N) | Setting | Recruitment Period | Inclusion/Exclusions criteria |
|---|---|---|---|---|
| Fan et al. (2017) (1) | Patients with lung (7), gastric (12), bone (7), and pancreas cancer (11) | Huai'an First People's Hospital and Maternal & Child Health Care Hospital of Huai'an City | February 2011 to May 2016 | Inclusion criteria: between 18 and 70 years old; first diagnosed as cancer within 3 months; and basic communication capability to complete the interview. Exclusion criteria: diagnosed with cardiorespiratory diseases; drug addiction history or sedative–hypnotic drug(s) use; neuropsychiatric or cognitive diseases or a related treatment history; suicidal attempts or ideation before cancer diagnosis; and family history of psychiatric history |
| Liu et al. (2021) (2) | Patients with breast cancer (303) | Fengcheng Hospital | June 2017 to June 2018 | Inclusion criteria: HAMD-17 8–24 score, and American Society of Anesthesiologists (ASA) score I-II before surgery Exclusion criteria: HAMD score less than or equal to 7 or greater than or equal to 24 before the study, psychiatric disorders such as mania and schizophrenia, and severe liver, renal, cardiovascular, or systematic inflammatory diseases. |
| Ren et al. (2022) (3) | Patients with colorectal cancer (104) | Gongli hospital | Jan 2015 to October 2017 | Inclusion criteria: American Society of Anesthesiologists (ASA) class I–II identification undergoing elective colorectal cancer surgery under general anesthesia for less than 4 h, the incision expected to be more than 10 cm, age between 40 and 70 years with the body mass index (BMI) ranging from 18 to 24 kg m2. Exclusion criteria: poor understanding and mental or central nervous system disorders before operation, presence of diabetes and heart disease, hormone therapy during operation, those with ketamine or opioid allergy, presence of severe liver and kidney dysfunction, alcohol addiction or frequent use of sedative and analgesic drugs. |
| Wang et al. (2020) (4) | Patients with cervical carcinoma (417) | Hospital of Shanghai University | April 2015 to July 2018 | Inclusion criteria: Hamilton Rating Scale for Depression scores within 8–24, and American Society of Anesthesiologists score of I-II. Exclusion criteria: Having mental diseases or psychiatric history such as schizophrenia and mania, receiving psychotropic substances, having severe system diseases such as heart, renal and liver diseases. |
| Xu et al. (2017) (5) | Patients with breast cancer (50) | Hospital of Nanchang University | May 2014 to March 2015 | Inclusion criteria: underwent modified radical mastectomy of unilateral breast cancer, age between 30 and 55 years old, have ≥ 5 years of education, American Society of Anesthesiologists I-II grade, HAMD score ≥ 17 points, were married and generational, mainly by the immediate family care after surgery. Exclusion criteria: antidepressant treatment within 2 months, preoperative radiotherapy and chemotherapy treatment, previous personality disorder, mental retardation, brain damage or brain disease, combined with schizophrenia, mania and other mental illness, hyperthyroidism or hypothyroidism, severe cardiovascular disease, diabetes, severe anemia, and heart, lung, liver, kidney function abnormalities, immune system diseases, or the use of drugs affecting the immune system obviously, pregnancy or lactation, a history of illicit drug use (such as marijuana, ecstasy, etc.), participation in other clinical trials, refused to participate. |
1. Fan W, Yang H, Sun Y, Zhang J, Li G, Zheng Y, et al. Ketamine rapidly relieves acute suicidal ideation in cancer patients: a randomized controlled clinical trial. Oncotarget. 2017;8(2):2356.
2. Liu P, Li P, Li Q, Yan H, Shi X, Liu C, et al. Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients. Journal of Investigative Surgery. 2021;34(8):883–8.
3. Ren Q, Hua L, Zhou X, Cheng Y, Lu M, Zhang C, et al. Effects of a Single Sub-Anesthetic Dose of Ketamine on Postoperative Emotional Responses and Inflammatory Factors in Colorectal Cancer Patients. Frontiers in Pharmacology. 2022;13.
4. Wang J, Wang Y, Xu X, Peng S, Xu F, Liu P. Use of various doses of S-ketamine in treatment of depression and pain in cervical carcinoma patients with mild/moderate depression after laparoscopic total hysterectomy. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2020;26:e922028–1.
5. Xu R, Zhan Y, Chen S. Effect of intraoperative single administration of sub-anesthesia ketamine on breast cancer patients with depression. BIOMEDICAL RESEARCH-INDIA. 2017;28.
All the included studies were randomized clinical trials and were conducted in China.