Figure 1.
Increased percentage of circulating CD4+ TEM cells in patients with GPA. (A) Representative flow cytometry dot plots of CD45RO and CCR7 expression to identify four CD4+ T cell subsets in the peripheral blood of a patient with GPA in remission (right plot) and a HC (left plot). (B) Percentages of CD45RO–CCR7+ (TNAIVE), CD45RO+CCR7+ (TCM), CD45RO+CCR7– (TEM) and CD45RO–CCR7– (TTD) subsets within the CD4+ T cell population in peripheral blood of patient with GPA in remission (filled squares; n = 27) and HCs (open circles; n = 16). Horizontal bar represent median percentage. **P < 0.01, ***P < 0.001 vs HCs. GPA: granulomatosis with polyangiitis; HC: healthy control; TEM: CD4+ effector memory T cells