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. 2023 Dec 3;42(12):113530. doi: 10.1016/j.celrep.2023.113530

Figure 5.

Figure 5

Increased IL-15-dependent glycolysis in NK cells from ECs

(A) Extracellular acidification rate (ECAR) of NK cells from ECs (n = 7), ARTs (n = 7), and HIVNs (n = 7) with or without 10 ng/mL IL-15 stimulation for 24 h was measured at indicated time points in response to glucose, oligomycin, and 2-DG using a Seahorse XFe96 Analyzer.

(B–D) Glycolysis (B), glycolytic capacity (C), and glycolytic reserve (D) of NK cells were compared in ECs, ARTs and HIVNs with or without 10 ng/mL IL-15 stimulation for 24 h. Paired t test was used to compare ECARs between stimulated and unstimulated cells, whereas one-way ANOVA test was used to compare ECARs among cohorts.

Horizontal lines in (B)–(D) represent medians. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.