Table 2.
Ventilator Settings at Baseline, 24 Hours, and 48 Hours
| Variables | Baseline |
24 Hours |
48 Hours |
|||
|---|---|---|---|---|---|---|
| Treatment Group | Control Group | Treatment Group | Control Group | Treatment Group | Control Group | |
| PaO2/FiO2 ratio, mm Hg | 177 (125–241) | 195 (120–235) | 196 (150–252) | 188 (130–263) | 200 (157–239) | 183 (122–235) |
| FiO2, % | 51.5 (40–70) | 60 (42.5–75) | 45 (36–57) | 50 (40–60) | 45 (38–60) | 50 (40–60) |
| PEEP, cm H2O | 12 (10–14) | 12 (10–14) | 12 (10–14) | 12 (10–14) | 12 (10–13) | 12 (10–14) |
| Plateau pressure, cm H2O | 24 (21–28) | 23 (21–27) | 24 (21–26) | 23 (20–26) | 24 (21–26) | 24 (20–26) |
| Respiratory system compliance, ml/cm H2O | 31.7 (24.1–37.5) | 32.0 (27.0–40.0) | 32.0 (25.5–41.9) | 32.0 (27.0–41.0) | 31.0 (25.0–38.0) | 35.0 (27.0–42.0) |
| Respiratory rate, breaths per min | 22 (20–25) | 22 (18–25) | 22 (20–25) | 23 (19–26) | 22 (18–26) | 24 (20–27) |
| Vt/IBW, ml/kg | 6.0 (6–6.8) | 6.0 (5.6–6.7) | 6.1 (5.6–6.6) | 6.0 (5.4–6.5) | 6.0 (5.5–6.5) | 5.9 (5.5–6.5) |
| e, L/min | 8.8 (7.1–10.1) | 8.4 (7.2–9.9) | 8.4 (7.5–10.1) | 8.7 (7.3–9.9) | 8.6 (7.0–10.2) | 8.7 (7.4–10.4) |
| Use of neuromuscular blockade | 53 (56) | 45 (45) | 46 (49) | 39 (39) | 46 (49) | 30 (30) |
| Lifting sedation | 0 (0) | 4 (4) | 0 (0) | 3 (3) | 1 (1) | 3 (3) |
Definition of abbreviations: IBW = ideal body weight; PEEP = positive end-expiratory pressure.
Data are presented as median (interquartile range) or n (%).