Table 5.

Exploratory Outcomes in the Final Analysis Population

Exploratory Outcomes	Treatment Group (n = 94)	Control Group (n = 99)	Difference or RR (95% CrI)
Requirement for VV-ECMO	4 (4.2)	5 (5.0)	RR, 0.70 (0.14 to 3.39)
Neurological signs and symptoms (Day 90)*	4 (4.2)	17 (17.2)	RR, 0.17 (0.04 to 0.62)
Motor	4 (4.2)	12 (12.1)	RR, 0.36 (0.08 to 1.42)
Sensory	0 (0.0)	14 (14.1)	RR, 0.01 (0.00 to 0.12)
Ventilator time, h, mean (SD)	447.1 (225.4)	448.6 (962.4)	33.73 (−187.52 to 254.18)

			Mean Difference (95% CrI)
Change in A–a gradient at 48 h			−28.8 (−59.8 to 1.0)
Change in SaO2 at 48 h			0.12 (0.00 to 0.24)
Change in ventilatory ratio at 48 h			−0.10 (−0.30 to 0.09)

Definition of abbreviations: CrI = credible interval; RR = risk ratio; VV-ECMO = veno-venous extracorporeal membrane oxygenation.

Data are presented as n (%) unless otherwise noted.

^*Measured at 90 days after randomization in survivors: 62 patients in the treatment group and 67 in the control group.