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. 2023 Dec 20;14:1310098. doi: 10.3389/fimmu.2023.1310098

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Copyright © 2023 Kargarpour, Cicko, Köhler, Zech, Stoshikj, Bal, Renner, Idzko and El-Gazzar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of P2ry2 expression in murine hematopoietic cells. Different bone marrow chimeric mice were treated with LPS i.t.: Wild type BM in P2ry2 ^+/+, Wild type BM in P2ry2 ^-/-, P2ry2 ^-/- BM in P2ry2 ^+/+, P2ry2 ^-/- BM in P2ry2 ^-/-, and then analyzed for lung inflammation. (A) The number of neutrophils and macrophages were evaluated in BALFs by flow cytometry. (B, C) Concentrations of cytokines IL-6, KC and IL-1β in BALF were measured by ELISA. Statistical analysis was based on Bonferroni post-test. Values are given as mean ± SEM. n = 4-6 mice in each group. *p < 0.05, **p < 0.01 versus P2ry2 ^+/+ BMCs in P2ry2 ^-/- LPS.