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. 2023 Dec 20;14:1272918. doi: 10.3389/fimmu.2023.1272918

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Copyright © 2023 Hioki, Ryan, Thesmar, Lynch, Pobezinsky and Pobezinskaya

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The majority of immune cells acquire tumor material within the TME. (A) Experimental design, and representative flow cytometry analysis of ZsG fluorescence in CD45+ TILs isolated from B16 and B16^ZsG tumors. (B–D) Total CD45+ TIL scRNA-seq data analyses. (B) UMAP visualization of scRNA-seq data from total (left), ZsG- (middle) and ZsG+ (right) TILs from B16^ZsG tumors. The number of analyzed single cells are indicated in parenthesis. (C) UMAP plots of re-clustered monocytes/macrophages. (D) UMAP plots of monocyte (left) and macrophage (middle) signatures in re-clustered monocytes/macrophages with key marker genes in each cluster (right).