Table 3.

Predictive binding energy of core proteins to trametinib

Gene symbol	Drug	Predictive binding energy (Kcal/mol)
HMGB2	Trametinib	−6.19
HMGA1	Trametinib	−7.31
FOXM1	Trametinib	−7.95
TCF19	Trametinib	−6.82
MYBL2	Trametinib	−6.27
CENPA	Trametinib	−6.77
ESR1	Trametinib	−5.92
E2F1	Trametinib	−4.48
ZIC2	Trametinib	−5.28