Table 2.
Univariate and multivariate Cox regression analyses of the training group
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Variables | HR (95% CI) | P | HR (95% CI) | P | |
| Age,years | |||||
| 20–35 | Reference | Reference | |||
| 35–59 | 1.119 (0.639–1.96) | 0.693 | 1.173 (0.680–2.025) | 0.564 | |
| 60–84 | 1.234 (0.809–2.176) | 0.466 | 1.279 (0.736–2.222) | 0.381 | |
| 85 + | 2.393 (1.227–4.666) | 0.010 | 2.362 (1.233–4.524) | < 0.01 | |
| Tumor size,cm | |||||
| ≤ 2 cm | Reference | ||||
| 2.1-5 cm | 0.849 (0.452–1.594) | 0.611 | — | — | |
| 5.1-10 cm | 1.584 (0.883–2.844) | 0.122 | — | — | |
| > 10 cm | 1.217 (0.675–2.195) | 0.513 | — | — | |
| Race | |||||
| Black | Reference | ||||
| White | 1.107 (0.875–1.402) | 0.394 | — | — | |
| Other | 0.830 (0.606–1.137) | 0.247 | — | — | |
| Year of diagnosis | — | — | |||
| 2010–2011 | Reference | ||||
| 2012–2013 | 0.912 (0.737–1.128) | 0.398 | — | — | |
| 2014–2015 | 0.868 (0.697–1.080) | 0.205 | — | — | |
| Laterality | |||||
| Left | Reference | ||||
| Right | 0.996 (0.838–1.184) | 0.966 | — | — | |
| Primary site | |||||
| C50.0 | Reference | ||||
| C50.1 | 0.924 (0.301–2.839) | 0.891 | — | — | |
| C50.2 | 1.118 (0.370–3.375) | 0.842 | — | — | |
| C50.3 | 1.651 (0.511–5.331) | 0.401 | — | — | |
| C50.4 | 1.316 (0.451–3.844) | 0.615 | — | — | |
| C50.5 | 1.401 (0.466–4.203) | 0.547 | — | — | |
| C50.6 | 0.331 (0.034–3.145) | 0.336 | — | — | |
| C50.8 | 1.165 (0.401–3.387) | 0.779 | — | — | |
| C50.9 | 1.272 (0.440–3.670) | 0.656 | — | — | |
| Histopathology | |||||
| Ductal | Reference | Reference | |||
| Lobular | 2.089 (1.293–3.375) | 0.003 | 1.907 (1.204–3.022) | < 0.01 | |
| Other | 1.289 (1.008–1.648) | 0.042 | 1.232 (0.972–1.562) | 0.083 | |
| Grade | |||||
| I ~ II | Reference | Reference | |||
| III | 1.547 (1.245–1.922) | < 0.01 | 1.607 (1.299–1.988) | < 0.01 | |
| Unknown | 1.528 (1.131–2.065) | 0.005 | 1.473 (1.101–1.973) | < 0.01 | |
| T stage | |||||
| T1 | Reference | ||||
| T2 | 1.661 (0.829–3.326) | 0.151 | — | — | |
| T3 | 1.011 (0.522–1.957) | 0.973 | — | — | |
| T4 | 1.270 (0.681–2.365) | 0.451 | — | — | |
| N stage | |||||
| N0 | Reference | ||||
| N1 | 1.187 (0.939–1.501) | 0.151 | — | — | |
| N2 | 1.258 (0.920–1.721) | 0.149 | — | — | |
| N3 | 1.182 (0.876–1.594) | 0.272 | — | — | |
| Marital status | |||||
| Unmarried | Reference | Reference | |||
| Married | 1.093 (0.895–1.334) | 0.380 | 1.039 (0.857–1.259) | 0.694 | |
| Other | 1.428 (1.098–1.857) | 0.007 | 1.347 (1.046–1.734) | 0.021 | |
| Bone metastasis | |||||
| No | Reference | Reference | |||
| Yes | 1.564 (1.274–1.921) | < 0.01 | 1.551 (1.277–1.883) | < 0.01 | |
| Unknown | 2.535 (1.055–6.092) | 0.037 | 2.899 (1.231–6.827) | 0.014 | |
| Brain metastasis | |||||
| No | Reference | Reference | |||
| Yes | 2.140 (1.607–2.848) | < 0.01 | 1.964 (1.521–2.535) | < 0.01 | |
| Unknown | 1.157 (0.708–1.889) | 0.559 | 1.242 (0.787–1.962) | 0.351 | |
| Liver metastasis | |||||
| No | Reference | Reference | |||
| Yes | 1.517 (1.242–1.854) | < 0.01 | 1.560 (1.284–1.895) | < 0.01 | |
| Unknown | 0.772 (0.381–1.563) | 0.472 | 0.732 (0.369–1.452) | 0.372 | |
| HER2 | |||||
| Negative | Reference | Reference | |||
| Positive | 0.585 (0.468–0.731) | < 0.01 | 0.586 (0.474–0.726) | < 0.01 | |
| Unknown | 0.941 (0.597–1.483) | 0.793 | 0.953 (0.608–1.491) | 0.833 | |
| ER | |||||
| Negative | Reference | Reference | |||
| Positive | 0.599 (0.458–0.785) | < 0.01 | 0.617 (0.473–0.804) | < 0.01 | |
| PR | |||||
| Negative | Reference | Reference | |||
| Positive | 0.626 (0.483–0.812) | < 0.01 | 0.622 (0.484–0.801) | < 0.01 | |
| Surgery | |||||
| No | Reference | Reference | |||
| Yes | 0.691 (0.539–0.883) | < 0.01 | 0.690 (0.546–0.871) | < 0.01 | |
| Neoadjuvant therapy | |||||
| No | Reference | Reference | |||
| Yes | 0.647 (0.460–0.911) | 0.01 | 0.651 (0.471–0.901) | < 0.01 | |
| Chemotherapy | |||||
| No | Reference | Reference | |||
| Yes | 0.697 (0.568–0.856) | < 0.01 | 0.704 (0.576–0.862) | < 0.01 | |
| Radiotherapy | |||||
| No | Reference | ||||
| Yes | 0.949 (0.770–1.170) | 0.625 | — | — | |
CI confidence interval, HR hazard ratio