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. 2024 Jan 4;21:4. doi: 10.1186/s12974-023-02996-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Different alterations of connexin and pannexin expression in the cochlea and auditory cortex after the oto/neurotoxic insult. A, B Representative bands of western blot showing high levels of Cx43 and Panx1 in the auditory cortex (ACx) of styrene-treated animals compared to controls. Bar graphs show optical density values in all samples (Cx43 n = 3 animals/group; Student’s t test, p = 0.03; Panx1 n = 3 animals/group; Student’s t test, p = 0.0001) normalized to the corresponding total protein levels (GAPDH). C–E Western blots showing expression levels of Cx26, Cx30 and Panx1 in cochlear lysates of styrene-treated animals compared to controls. Bar graphs show densitometric analyses (Cx26, n = 3 animals/group; Student’s t test, p = 0.04; Cx30, n = 3 animals/group; Student’s t test, p = 0.017; Panx1, n = 3 animals/group; Student’s t test, p > 0.05). Asterisks indicate significant differences between groups (*p < 0.05; ***p < 0.001)