Table 1.
Baseline characteristics of individuals stratified by tertiles of SII
| Variables | Total (n = 1677) |
Tertiles 1 (n = 559) |
Tertiles 2 (n = 559) |
Tertiles 3 (n = 559) |
p value |
|---|---|---|---|---|---|
| Sex, female(%) | 743 (44.3) | 276 (49.5) | 237 (42.3) | 230 (41.1) | 0.010 |
| Age(years) | 50.5 ± 14.0 | 49.3 ± 14.4 | 50.3 ± 13.6 | 52.0 ± 14.0 | 0.005 |
| Diabetes, n(%) | 377 (22.5) | 101 (18.1) | 129 (23.1) | 147 (26.3) | 0.004 |
| Hypertension, n(%) | 1299 (77.6) | 427 (76.7) | 425 (76.2) | 447 (80) | 0.254 |
| Stroke, n(%) | 80 ( 9.4) | 24 (10.2) | 30 (10.4) | 26 (7.9) | 0.499 |
| CVD, n(%) | 199 (23.4) | 52 (21.7) | 59 (21) | 88 (26.6) | 0.203 |
| Systolic pressure(mmhg) | 144.0 ± 24.1 | 142.0 ± 22.5 | 145.3 ± 24.5 | 144.7 ± 25.2 | 0.081 |
| Diastolic pressure(mmhg) | 85.4 ± 15.1 | 85.5 ± 15.1 | 86.1 ± 14.6 | 84.6 ± 15.7 | 0.341 |
| Medication | |||||
| CCB, n (%) | 1221 (78.2) | 395 (76.4) | 410 (77.1) | 416 (81.2) | 0.124 |
| ACEI, n (%) | 81 (5.7) | 28 (5.9) | 21 (4.4) | 32 (6.8) | 0.265 |
| ARB, n (%) | 564 (38.2) | 172 (35.4) | 183 (36.6) | 209 (42.7) | 0.043 |
| Statin, n (%) | 219 (14.9) | 53 (10.9) | 76 (15.4) | 90 (18.5) | 0.004 |
| Aspirin, n (%) | 174 (12.0) | 37 (7.7) | 55 (11.3) | 82 (17) | < 0.001 |
| Laboratory variables | |||||
| White blood cell(10^9/L) | 6.5 ± 2.3 | 5.1 ± 1.5 | 6.3 ± 1.7 | 8.1 ± 2.6 | < 0.001 |
| Platelet(10^9/L) | 194.3 ± 80.5 | 142.8 ± 57.4 | 192.7 ± 59.7 | 247.3 ± 84.5 | < 0.001 |
| Hemoglobin(g/L) | 89.4 ± 22.1 | 86.2 ± 22.5 | 90.2 ± 22.6 | 91.8 ± 20.8 | < 0.001 |
| Neutrophils(10^9/L) | 4.5 ± 2.1 | 3.1 ± 1.0 | 4.3 ± 1.3 | 6.1 ± 2.3 | < 0.001 |
| Monocyte(10^9/L) | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.5 ± 0.2 | < 0.001 |
| Lymphocyte(10^9/L) | 1.3 ± 0.5 | 1.4 ± 0.6 | 1.3 ± 0.5 | 1.1 ± 0.4 | < 0.001 |
| Serum creatinine(umol/L) | 788.4 ± 318.2 | 801.2 ± 323.8 | 797.6 ± 318.1 | 766.5 ± 312.0 | 0.133 |
| Urea nitrogen(mmol/L) | 22.4 ± 14.9 | 23.0 ± 9.6 | 22.1 ± 9.2 | 22.1 ± 22.2 | 0.526 |
| Albumin(g/L) | 36.0 ± 5.7 | 36.2 ± 5.5 | 36.3 ± 5.5 | 35.4 ± 6.1 | 0.016 |
| Alkaline phosphatase(U/L) | 84.6 ± 61.7 | 84.3 ± 73.3 | 82.3 ± 55.1 | 87.4 ± 55.0 | 0.374 |
| Aspartate aminotransferase(U/L) | 21.6 ± 15.1 | 22.1 ± 14.9 | 21.1 ± 16.4 | 21.7 ± 14.0 | 0.489 |
| Alanine aminotransferase(U/L) | 18.9 ± 24.5 | 20.3 ± 31.1 | 18.9 ± 23.7 | 17.5 ± 16.3 | 0.162 |
| Total bilirubin(umol/L) | 4.9 ± 3.1 | 5.0 ± 3.5 | 4.7 ± 2.6 | 5.0 ± 3.0 | 0.214 |
| Cholesterol(mmol/L) | 4.5 ± 1.3 | 4.3 ± 1.2 | 4.6 ± 1.4 | 4.7 ± 1.3 | < 0.001 |
| Triglyceride(mmol/L) | 1.6 ± 1.2 | 1.4 ± 0.9 | 1.7 ± 1.6 | 1.6 ± 1.0 | < 0.001 |
| High density lipoprotein(mmol/L) | 1.2 ± 0.4 | 1.2 ± 0.4 | 1.2 ± 0.4 | 1.2 ± 0.4 | 0.900 |
| Low density lipoprotein(mmol/L) | 2.8 ± 6.5 | 2.6 ± 1.0 | 3.1 ± 1.1 | 2.8 ± 1.0 | 0.380 |
| iPTH(pg/ml) | 198.0 (96.6, 351.4) | 214.2 (114.3, 361.3) | 199.4 (97.7, 352.5) | 179.8 (68.1, 338.0) | 0.017 |
| Calcium(mmol/L) | 2.1 ± 0.3 | 2.0 ± 0.3 | 2.1 ± 0.3 | 2.1 ± 0.3 | < 0.001 |
| Phosphorus(mmol/L) | 1.8 ± 2.8 | 1.8 ± 0.5 | 2.0 ± 4.7 | 1.7 ± 0.6 | 0.364 |
| Magnesium(mmol/L) | 0.9 ± 0.4 | 0.9 ± 0.4 | 0.9 ± 0.3 | 0.9 ± 0.5 | 0.369 |
| sCRP(mg/l) | 3.2 (1.3, 8.5) | 2.7 (1.2, 5.8) | 3.0 (1.2, 6.5) | 4.2 (1.6, 12.0) | < 0.001 |
| Total Kt/V | 2.3 ± 1.2 | 2.3 ± 1.0 | 2.4 ± 1.7 | 2.3 ± 0.9 | 0.420 |
| RRF(mL/min/1.73m2) | 4.1 ± 3.6 | 3.9 ± 3.2 | 4.2 ± 3.5 | 4.1 ± 3.9 | 0.416 |
| SII (10^9/L) | 611.1 (393.0, 963.0) | 316.8 (240.3, 392.4) | 610.9 (525.8, 710.4) | 1214.0 (963.0, 1696.0) | < 0.001 |
Abbreviations: CVD cardiovascular diseases, CCB calcium channel blocker, ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, iPTH intact parathyroid hormone, sCRP sensitive C-reactive protein, Total Kt/V K, dialyzer clearance of urea; t dialysis time; V volume of distribution of urea, RRF renal residual function, SII systemic immune inflammation index