Table 3.
Subgroup analysis for the association of SII stratification and all-cause mortality in PD patients
| Variables | Tertiles 1 | Tertiles 2 | Tertiles 3 | P for interaction | ||
|---|---|---|---|---|---|---|
| HR(95%CI) | p value | HR(95%CI) | p value | |||
| Age | 0.891 | |||||
| < 65 years | 1.00 | 1.49 (0.79 ~ 2.82) | 0.216 | 2.09 (1.16 ~ 3.76) | 0.014 | |
| ≥ 65 years | 1.00 | 1.07 (0.25 ~ 4.55) | 0.929 | 0.92 (0.26 ~ 3.28) | 0.894 | |
| Gender | 0.310 | |||||
| Male | 1.00 | 0.84 (0.32 ~ 2.21) | 0.723 | 1.49 (0.63 ~ 3.5) | 0.362 | |
| Female | 1.00 | 1.7 (0.86 ~ 3.37) | 0.129 | 1.88 (1 ~ 3.53) | 0.052 | |
| Hypertension | 0.756 | |||||
| No | 1.00 | 0.82 (0.44 ~ 1.51) | 0.524 | 1.7 (0.97 ~ 2.99) | 0.065 | |
| Yes | 1.00 | 1.67 (0.96 ~ 2.91) | 0.071 | 1.93 (1.16 ~ 3.22) | 0.011 | |
| Diabetes | 0.925 | |||||
| No | 1.00 | 1.15 (0.63 ~ 2.07) | 0.652 | 1.48 (0.85 ~ 2.59) | 0.169 | |
| Yes | 1.00 | 1.14 (0.3 ~ 4.29) | 0.846 | 5.62 (1.2 ~ 26.43) | 0.029 | |
| Pre-existing cardiovascular disease | 0.251 | |||||
| No | 1.00 | 1.53 (0.79 ~ 2.94) | 0.207 | 2.54 (1.35 ~ 4.8) | 0.004 | |
| Yes | 1.00 | 1.95 (0.66 ~ 5.75) | 0.226 | 2.9 (0.88 ~ 9.56) | 0.079 | |
Abbreviations: SII systemic inflammatory index, Total Kt/V K, dialyzer clearance of urea; t dialysis time, V volume of distribution of urea, RRF renal residual function, iPTH intact parathyroid hormone, HR hazard ratio, CI confidence interval; adjusted for age, sex, diabetes mellitus, hypertension, strokes, pre-existing cardiovascular disease, drug medication, total Kt/V RRF, hemoglobin, urea nitrogen, Serum creatinine, albumin, cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, alkaline phosphatase, magnesium, calcium, phosphorus, iPTH aspartate aminotransferase, alanine aminotransferase, total bilirubin