Table 1.

Expression signal (log2) and fold change of selected pro-inflammatory cytokines. * marks significant differences of ‘old’ compared to ‘young’ in the same condition (p < 0.05), based on the p-value analyzed using the Transcriptome Analysis Console Software (TAC 4.0, Thermo Fisher Scientific)

Gene	Ctrl young	Ctrl old	fold change	p-value	PAO1 young	PAO1 old	fold change	p-value	D61 young	D61 old	fold change	p-value
Tnf	8.71	9.99	2.4	0.0512	12.01	13.84	3.6	0.0342*	13.96	15.13	2.3	0.1439
Il1b	13.39	15.19	3.5	0.0181*	15.84	17.47	3.1	0.0430*	16.66	18.10	2.7	0.1129
Il6	13.66	14.72	2.1	0.0391*	15.92	16.38	1.4	0.1036	16.96	17.65	1.6	0.2281
Ccl3	14.41	15.54	2.2	0.0922	17.27	18.48	2.3	0.2546	18.56	19.23	1.6	0.5090
Ccl20	9.00	6.61	-5.3	0.8400	12.44	14.05	3.0	0.6498	13.70	13.78	1.1	0.7384
Cxcl1	15.23	16.27	2.1	0.0046*	18.23	18.60	1.3	0.4739	18.55	18.43	-1.1	0.8377
Il17a	6.30	6.22	-1.1	0.7365	6.54	7.88	2.5	0.0127*	6.89	8.23	2.5	< 0.001*