Table 2.

Characteristics of the 56 proteins differentially abundant when compared the proteomic profiles from persisters and growing cells (T48hcip vs. Expo)

Gene	Protein annotation (Uniprot)	Protein description	Log2 FC T48hcip vs. Expoa	Log2 FC T48h vs. Expob
11,191	I3U1C7	M15B subfamily muramoylpentapeptide carboxypeptidase	-8.20	-5.82
10,503	I3U1A5	Peptidoglycan-binding protein	-6.80	-3.53
11,429	Q3XXV0	Amino acid ABC superfamily ATP binding cassette transporter, binding protein	-5.44	-4.33
mtlD	Q3Y1G8	Mannitol-1-phosphate 5-dehydrogenase	-4.48
galP	Q3Y292	MFS transporter, SP family galactose:H + symporter	-4.35
sagA	I3U595	Secreted antigen A	-4.32	-2.17
11,462	Q3Y0G5	Uncharacterized protein	-4.00
12,555	Q3Y185	ErfK/YbiS/YcfS/YnhG family protein	-3.66	-4.78
ppiA	Q3XZ44	Foldase protein PrsA	-3.66	1.83
rseP	I3U2R6	Zinc metalloprotease	-3.50
10,635	Q3Y0A7	Uncharacterized protein	-3.48
cysK	Q3XX46	Cysteine synthase	-3.46
10,888	Q3Y2R0	Flavodoxin	-3.36	-1.56
10,870	Q3Y2P3	Bacteriophage minor structural protein	-3.30
mdoB	Q3XZ26	Phosphatidylglycerol–membrane-oligosaccharide glycerophosphotransferase	-2.94
murA	Q3XY92	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-2.84	-1.72
11,465	Q3Y0G2	Protein of hypothetical function DUF984	-2.80
rpmG	I3U4T5	50 S ribosomal protein L33	-2.48	-2.94
rpsN	Q3XYX6	30 S ribosomal protein S14 type Z	-2.26
mvk	Q3XZL3	Mevalonate kinase	-2.24
10,382	I3TZ18	NADH:flavin oxidoreductase/NADH oxidase	-2.09	-2.02
10,028	Q3XYZ5	Haloacid dehalogenase (HAD) superfamily hydrolase	-1.92	-2.50
pyrD2	I3U217	Dihydroorotate oxidase (fumarate)	-1.90
12,850	Q3Y0Z2	Uncharacterized protein	-1.82
clpX	Q3XZ71	ATP-dependent Clp protease ATP-binding subunit ClpX	-1.82
12,761	I3U5U7	Uncharacterized protein	-1.78
11,804	Q3Y303	MarR family transcriptional regulator	-1.72
pgsA	Q3Y0P3	CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	-1.69
murB	Q3Y1W9	UDP-N-acetylenolpyruvoylglucosamine reductase	-1.67
mobC	I3U5U5	Mobilization protein C	-1.57	-3.45
12,063	I3U3U9	M20/M25/M40 family peptidase	1.51
polA	I3U2E8	DNA polymerase I	1.51
erpQ	Q3XZG3	ErpQ protein	1.54
cspA	I3U0N2	Cold shock protein Csp	1.57	-6.12
pdp	Q3XXR6	Pyrimidine-nucleoside phosphorylase	1.59
accA	Q3Y0R8	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha	1.68	2.74
glpF	Q3XYL4	Glycerol MIP family major intrinsic protein channel protein	1.74	2.59
10,691	Q3Y1 × 6	Flavin reductase	1.78
papS	I3U153	Poly A polymerase	1.96
uxuA	Q3XZP4	Mannonate dehydratase	1.97
ahpC	Q3XZP1	Alkyl hydroperoxide reductase C	2.02
dacA	I3U3E0	Serine-type D-Ala-D-Ala carboxypeptidase	2.05	4.42
panE	Q3Y316	2-dehydropantoate 2-reductase	2.06
dps	I3U5I6	DNA-binding protein Dps	2.10
cad	I3U5L5	Sex pheromone cAD1	2.24
rbsR	I3TZ89	Ribose transcriptional regulator	2.33
mdlA	Q3XXU7	Multidrug ABC superfamily ATP binding cassette transporter, ABC/membrane protein	2.35	1.70
12,664	I3U5K0	LacI family transcriptional regulator	2.53	2.55
pphA	I3U2F5	Phosphoprotein phosphatase	2.56	2.03
12,270	Q3XWI3	GNAT family acetyltransferase	2.78
10,507	I3TZE3	GyrI-like domain-containing protein	2.79
qor	I3TYH2	NADPH:quinone reductase	3.03
11,264	I3U1K0	Uncharacterized protein	3.27
msrA4	Q3XZS1	Peptide methionine sulfoxide reductase MsrA	3.65	2.17
nusB	Q3Y2G2	Transcription antitermination protein NusB	3.76	2.11
tufA;tufA2	Q3XX23	Elongation factor Tu	3.80	2.26

^a Fold change in abundance. Negative value indicates that the protein was less abundant in persisters than in growing cells.

^b Fold changes are indicated when the proteins were also identified as stationary phase proteins (T_48h vs. Expo).