Table 3.
Output of Cox regression model of time to first hospitalisation and time to first ILD-hospitalisation analysis by GAP Index (n=601) and ILD subtype (n=468)
| Time to first hospitalisation | Time to first ILD-hospitalisation | |||
|---|---|---|---|---|
| HR [95% CI] | p value (Wald test) |
HR [95% CI] | p value (Wald test) |
|
| GAP Index | ||||
| II vs. I |
2.5 [1.91, 3.27] |
< 0.001 |
2.36 [1.67, 3.33] |
< 0.001 |
| III vs. I |
2.99 [2.24, 3.99] |
< 0.001 |
3.13 [2.2, 4.47] |
< 0.001 |
| No PFT vs. I |
2.14 [1.36, 3.36] |
< 0.001 |
2.34 [1.35, 4.05] |
0.002 |
| ILD Subtype | ||||
| Granulomatous lung diseases vs. IPF |
0.35 [0.25, 0.48] |
< 0.001 |
0.23 [0.15, 0.36] |
< 0.001 |
| HP vs. IPF |
0.82 [0.58, 1.18] |
0.287 |
0.96 [0.64, 1.44] |
0.844 |
| CTD-ILD vs. IPF |
1.59 [1.1, 2.3] |
0.014 |
1.53 [0.99, 2.36] |
0.055 |
| Pneumoconiosis vs. IPF |
0.68 [0.3, 1.54] |
0.353 |
0.14 [0.02, 1.02] |
0.052 |
| Drug related ILD vs. IPF |
0.97 [0.51, 1.85] |
0.936 |
0.89 [0.41, 1.9] |
0.758 |
| Radiotherapy associated ILD vs. IPF |
0.92 [0.34, 2.49] |
0.873 |
0.34 [0.05, 2.44] |
0.283 |
| CPFE vs. IPF |
1.29 [0.7, 2.38] |
0.412 |
0.97 [0.43, 2.2] |
0.936 |
For these analyses, Hazard Ratios were drawn from a comparison of the most relevant ILD subtypes and IPF. HR= Hazard Ratio, CI= confidence interval, No PFT= No pulmonary function testing, IPF= Idiopathic pulmonary fibrosis, HP= Hypersensitivity pneumonitis, CTD-ILD= Rheumatic and connective tissue diseases with pulmonary involvement, CPFE= Fibrosis in emphysema patients without signs of other ILDs