FIGURE 2.

Assessment of mechanistic kidney model in predicting tenofovir (TFV) renal clearance (CL_r). Linear regression model (a, c, e) using CL_r of iohexol (iGFR) alone is compared to the mechanistic kidney model (b, d, f) which incorporates iGFR, kidney blood flow (via isovalerylglycine clearance), and OAT‐mediated secretory clearance (via kynurenic acid clearance). Goodness‐of‐fit plots show the comparison between individual prediction of TFV CL_r and individual observation of TFV CL_r, with adjusted R‐square, Pearson r, and Spearman ρ displayed (a, b). Error plots show the individual absolute prediction error (c, d) and individual normalized prediction error (e, f) with mean error, average fold error, and absolute average fold error displayed. Blue circles represent individual data, red dashed lines represent twofold error, and red solid lines represent error‐free.