TABLE 2.

Parameter values for the biomarker and drugs in the physiologically‐based mechanistic kidney model.

Parameter	Kynurenic acid	Tenofovir	Oseltamivir carboxylate
Molecular weight, g/mol	189.2	287.2	284.4
LogP	1.16	−1.6	−1.3
Unbound fraction in plasma (f u,p)	0.07 a	0.993 b	0.97 c
Blood‐to‐plasma ratio	1 d	0.55 e	0.67 f
Permeability (10−6 cm/s)	1 d	0.37 e	1.49 g

^a Based on refs. [17, 22, 23, 24].

^b Based on ref. [25].

^c Based on ref. [26].

^d Assumed.

^e Based on ref. [35].

^f Based on ref. [36].

^g Based on ref. [37].